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1. WO2013163337 - COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME

Publication Number WO/2013/163337
Publication Date 31.10.2013
International Application No. PCT/US2013/038053
International Filing Date 24.04.2013
IPC
A61K 39/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
CPC
A61K 2039/5252
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5252inactivated (killed)
A61K 2039/5258
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5258Virus-like particles
A61K 2039/541
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
54characterised by the route of administration
541Mucosal route
A61K 2039/543
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
54characterised by the route of administration
541Mucosal route
543intranasal
A61K 2039/545
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
545characterised by the dose, timing or administration schedule
A61K 2039/552
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
55characterised by the host/recipient, e.g. newborn with maternal antibodies
552Veterinary vaccine
Applicants
  • OHIO STATE INNOVATION FOUNDATION [US]/[US]
Inventors
  • GOURAPURA, Renukaradhya, J.
  • DWIVEDI, Varun
  • MANICKAM, Cordelia
  • PATTERSON, Ruthi
Agents
  • MARTY, Scott, D.
Priority Data
61/637,54724.04.2012US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME
(FR) COMPOSITIONS ET MÉTHODES DE TRAITEMENT ET DE PRÉVENTION DU SYNDROME DYSGÉNÉSIQUE ET RESPIRATOIRE DU PORC
Abstract
(EN)
Disclosed herein are methods and compositions for treating or preventing Porcine reproductive and respiratory syndrome (PRRS) infection in a subject. Described herein are compositions comprising an immunogenic porcine reproductive and respiratory syndrome virus (PRRSV) antigen and a nanoparticle. The compositions, immunogenic compositions and vaccines described herein can further comprise one or more adjuvants. The adjuvant can be any composition, pharmacological or immunological agent that modifies the effect of other agents, such as the antigens described herein. In some embodiments, the compositions, immunogenic compositions and vaccines described herein can further comprise both Mycobacterium tuberculosis whole cell lysate, Mycobacterium smegmatis whole cell lysate, and Mycobacterium vaccae whole cell lysate.
(FR)
La présente invention concerne des méthodes et des compositions de traitement ou de prévention d'une infection par le syndrome dysgénésique et respiratoire du porc chez un sujet. L'invention concerne des compositions renfermant un antigène immunogène du virus du syndrome dysgénésique et respiratoire du porc (PRRSV) et une nanoparticule. Les compositions, compositions immunogènes et vaccins décrits ici peuvent également renfermer un ou plusieurs adjuvants. L'adjuvant peut être toute composition ou tout agent pharmacologique ou immunologique qui modifie l'effet d'autres agents, tels que les antigènes décrits ici. Dans certains modes de réalisation, les compositions, compositions immunogènes et vaccins décrits ici peuvent également comprendre un lysat de cellules entières de Mycobacterium tuberculosis, un lysat de cellules entières de Mycobacterium smegmatis et un lysat de cellules entières de Mycobacterium vaccae.
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