WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2013162828) USE OF CPG OLIGONUCLEOTIDES CO-FORMULATED WITH AN ANTIBIOTIC TO ACCELARATE WOUND HEALING
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/162828    International Application No.:    PCT/US2013/034639
Publication Date: 31.10.2013 International Filing Date: 29.03.2013
IPC:
A61K 38/12 (2006.01), A61K 9/00 (2006.01), A61K 31/4745 (2006.01), A61K 31/711 (2006.01), A61P 17/02 (2006.01)
Applicants: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; National Institutes Of Health Office Of Technology Transfer 6011 Executive Boulevard Suite 325, Msc 7660 Bethesda, MD 20852-7660 (US)
Inventors: KLINMAN, Dennis, M.; (US).
ITO, Hiroyaso; (JP)
Agent: SIEGEL, Susan, Alpert; Klarquist Sparkman, LLP One World Trade Center, Suite 1600 121 SW Salmon Street Portland, OR 97204 (US)
Priority Data:
61/639,688 27.04.2012 US
Title (EN) USE OF CPG OLIGONUCLEOTIDES CO-FORMULATED WITH AN ANTIBIOTIC TO ACCELARATE WOUND HEALING
(FR) UTILISATION D'OLIGONUCLÉOTIDES CPG CO-FORMULÉS AVEC UN ANTIBIOTIQUE POUR ACCÉLÉRER LA CICATRISATION DES PLAIES
Abstract: front page image
(EN)Pharmaceutical compositions are provided that include an antibiotics, but that include ingredients that counteract the effect of that antibiotic on wound healing, without altering the bactericidal properties of the antibiotic. These pharmaceutical compositions include an effective amount of 1) an imidazoquinoline having toll-like receptor 7 (TLR7) ligand activity, 2) an immuno stimulatory K-type CpG oligodeoxynucleotide (ODN) comprising an unmethylated CpG motif, 3) an antibiotic, and 4) a surfactant, wherein the composition is formulated for topical administration. Methods for accelerating wound healing are also provided. These methods include topically administering the disclosed compositions. The wound can be in the skin or in the eye.
(FR)La présente invention concerne des compositions pharmaceutiques qui comprennent un antibiotique, mais qui comprennent aussi des composants qui contrebalancent l'effet de cet antibiotique sur la cicatrisation des plaies, sans modifier les propriétés bactéricides de l'antibiotique. Ces compositions pharmaceutiques comprennent une quantité efficace de 1) une imidazoquinoléine ayant une activité de ligand de récepteur toll-like 7 (TLR7), 2) un oligodésoxynucléotide CpG de type K immunostimulateur (ODN) comprenant un motif CpG non méthylé, 3) un antibiotique, et 4) un tensioactif, la composition étant formulée pour administration topique. La présente invention concerne en outre des procédés pour accélérer la cicatrisation des plaies. Ces procédés comprennent l'administration topique des compositions décrites. La plaie peut être sur la peau ou dans l'œil.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)