WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2013162772) PERFORIN 2 DEFENSE AGAINST INVASIVE AND MULTIDRUG RESISTANT PATHOGENS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/162772    International Application No.:    PCT/US2013/032503
Publication Date: 31.10.2013 International Filing Date: 15.03.2013
IPC:
C07K 14/705 (2006.01), G01N 33/50 (2006.01)
Applicants: UNIVERSITY OF MIAMI [US/US]; Office of Technology Transfer 1400 NW 10th Avenue 12th Floor Miami, Florida 33136 (US)
Inventors: DE ARMAS, Lesley; (US).
LYAPICHEV, Kirill; (US).
MCCORMACK, Ryan; (US).
PODACK, Eckhard; (US)
Agent: RAY, Denise M.; Alston & Bird LLP Bank of America Plaza 101 South Tryon Street Suite 4000 Charlotte, NC 28280-4000 (US)
Priority Data:
61/637,455 24.04.2012 US
Title (EN) PERFORIN 2 DEFENSE AGAINST INVASIVE AND MULTIDRUG RESISTANT PATHOGENS
(FR) DÉFENSE PAR LA PERFORINE-2 CONTRE DES PATHOGÈNES INVASIFS ET POLYRÉSISTANTS
Abstract: front page image
(EN)Perforin-2 (P2) is expressed by fibroblasts, microglia and macrophages and was found to be responsible for killing bacteria, for example, Mycobacteria smegmatis, M. avium, Salmonellae, MRSA (drug resistant Stapholococci), E coli. Compounds identified by screening assays are selected based on the effects of these compounds on P2. Use of these compounds in the treatment of infectious diseases, in particular, bacteria and antibiotic-resistant bacteria is also provided.
(FR)La perforine-2 (P2) est exprimée par les fibroblastes, la microglie et les macrophages et s'est avérée être responsable de la destruction de bactéries, par exemple Mycobacterium smegmatis, M. avium, les salmonelles, SARM (staphylocoques résistant aux médicaments), E. coli. Des composés identifiés par criblage sont sélectionnés sur la base des effets de ces composés sur P2. L'invention concerne ces composés dans le traitement de maladies infectieuses, en particulier, des bactéries et des bactéries résistant aux antibiotiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)