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1. WO2013162760 - NOVEL CYCLOTIDES WITH ANTICANCER ACTIVITY

Publication Number WO/2013/162760
Publication Date 31.10.2013
International Application No. PCT/US2013/032065
International Filing Date 15.03.2013
IPC
C07K 19/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
C07K 14/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A61K 38/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C12N 15/62 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
62DNA sequences coding for fusion proteins
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 14/4746
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4746p53
C07K 2319/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
C07K 2319/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
01containing a localisation/targetting motif
02containing a signal sequence
C07K 2319/50
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
50containing protease site
Applicants
  • UNIVERSITY OF SOUTHERN CALIFORNIA [US]/[US]
Inventors
  • CAMARERO, Julio, A.
  • ELNAGAR, Ahmed
  • JI, Yanbin
  • BI, Tao
Agents
  • KONSKI, Antoinette, F.
Priority Data
61/638,43325.04.2012US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL CYCLOTIDES WITH ANTICANCER ACTIVITY
(FR) NOUVEAUX CYCLOTIDES PRÉSENTANT UNE ACTIVITÉ ANTICANCÉREUSE
Abstract
(EN)
Compositions and method are disclosed for treating a disease or condition related to p53 misregulation or dysfunction. The compositions utilize a p53 cyclotide that inhibits p53 dysregulation or inhibition.
(FR)
La présente invention concerne des compositions et une méthode destinées à traiter une maladie ou un état pathologique liés à une mauvaise régulation ou à un dysfonctionnement de p53. Les compositions selon l'invention font appel à un cyclotide p53 qui inhibe la dysrégulation ou l'inhibition de p53.
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