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1. (WO2013162648) CELL SYSTEMS AND METHODS FOR IMPROVING FATTY ACID SYNTHESIS BY EXPRESSION OF DEHYDROGENASES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/162648 International Application No.: PCT/US2012/067901
Publication Date: 31.10.2013 International Filing Date: 05.12.2012
IPC:
C12P 7/64 (2006.01) ,C12N 9/02 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7
Preparation of oxygen-containing organic compounds
64
Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
02
Oxidoreductases (1.), e.g. luciferase
Applicants:
EXXONMOBIL RESEARCH AND ENGINEERING COMPANY; 1545 Route 22 East P.O. Box 900 Annandale, NJ 08801-0900, US
Inventors:
BROWN, Robert, C.; US
COPPERSMITH, Jennifer; US
PRAKASH, Prachee; US
AKELLA, Srividya; US
SESHADRI, Rekha; US
Agent:
RAKERS, Leanne, M.; Harness, Dickey & Pierce, P.L.C. 7700 Bonhomme Avenue Suite 400 St. Louis, MO 63105, US
Priority Data:
13/453,23523.04.2012US
Title (EN) CELL SYSTEMS AND METHODS FOR IMPROVING FATTY ACID SYNTHESIS BY EXPRESSION OF DEHYDROGENASES
(FR) SYSTÈMES CELLULAIRES ET MÉTHODES D'AMÉLIORATION DE LA SYNTHÈSE D'ACIDES GRAS PAR LE BIAIS DE L'EXPRESSION DE DÉSHYDROGÉNASES
Abstract:
(EN) The invention relates to methods for producing lipids such as fatty acid products in recombinant host cells engineered to express a non-native gene encoding a dehydrogenase. The recombinant microorganisms are able to proliferate at a higher rate as compared with microorganisms that do not express a non-native dehydrogenase gene, and cultures of microorganisms that are engineered for lipid production and that express a non-native dehydrogenase produce more lipid than cultures of control microorganisms that do not include a non-native dehydrogenase gene.
(FR) La présente invention concerne des procédés de production de lipides tels que des produits acides gras dans des cellules hôtes recombinées modifiées pour exprimer un gène non-natif codant pour une déshydrogénase. Les microorganismes recombinés sont capables de proliférer à une vitesse plus élevée par rapport à des microorganismes qui n'expriment pas de gène codant pour une déshydrogénase non-native, et les cultures des microorganismes qui sont modifiés de sorte à produire des lipides et qui expriment une déshydrogénase non-native produisent plus de lipides que les cultures de microorganismes de contrôle qui ne comprennent pas de gène codant pour une déshydrogénase non-native.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)