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1. (WO2013162078) THERAPEUTIC AGENT FOR INJURY IN EPITHELIUM AND ENDOTHELIUM
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/162078 International Application No.: PCT/JP2013/062989
Publication Date: 31.10.2013 International Filing Date: 30.04.2013
Chapter 2 Demand Filed: 20.11.2013
IPC:
C07K 14/745 (2006.01) ,A61K 38/00 (2006.01) ,A61P 7/02 (2006.01) ,A61P 7/10 (2006.01) ,A61P 9/10 (2006.01) ,A61P 9/14 (2006.01) ,A61P 11/06 (2006.01) ,A61P 31/04 (2006.01) ,A61P 43/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
745
Blood coagulation or fibrinolysis factors
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7
Drugs for disorders of the blood or the extracellular fluid
02
Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7
Drugs for disorders of the blood or the extracellular fluid
10
Antioedematous agents; Diuretics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
10
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
14
Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
06
Antiasthmatics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
Applicants:
学校法人日本大学 NIHON UNIVERSITY [JP/JP]; 東京都千代田区九段南四丁目8番24号 8-24, Kudan-minami 4-chome, Chiyoda-ku, Tokyo 1028275, JP
Inventors:
日臺 智明 HIDAI, Chiaki; JP
北野 尚孝 KITANO, Hisataka; JP
真宮 淳 MAMIYA, Atsushi; JP
Agent:
小林 浩 KOBAYASHI, Hiroshi; 東京都中央区八重洲二丁目8番7号福岡ビル9階 阿部・井窪・片山法律事務所 ABE, IKUBO & KATAYAMA, Fukuoka Bldg. 9th Fl., 8-7, Yaesu 2-chome, Chuo-ku, Tokyo 1040028, JP
Priority Data:
2012-10291027.04.2012JP
Title (EN) THERAPEUTIC AGENT FOR INJURY IN EPITHELIUM AND ENDOTHELIUM
(FR) AGENT THÉRAPEUTIQUE POUR UNE LÉSION DANS UN ÉPITHÉLIUM ET UN ENDOTHÉLIUM
(JA) 上皮及び内皮損傷の治療剤
Abstract:
(EN) The present invention provides: a therapeutic agent for injury in an epithelium and an endothelium, particularly minute injury in an epithelium and an endothelium; and others. The therapeutic agent according to the present invention is characterized by comprising, for example, a peptide (a) or (b) as mentioned below, a derivative of the peptide, or a salt of the peptide or the derivative: (a) a peptide comprising an amino acid sequence represented by any one of SEQ ID NOs: 10, 4, 12 and 6; and (b) a peptide comprising an amino acid sequence represented by any one of SEQ ID NOs: 16, 18, 20 and 22.
(FR) La présente invention concerne : un agent thérapeutique pour une lésion dans un épithélium et un endothélium, en particulier une lésion minuscule dans un épithélium et un endothélium ; et autres. L'agent thérapeutique selon la présente invention est caractérisé en ce qu'il comprend, par exemple, un peptide (a) ou (b) tel que mentionné ci-après, un dérivé du peptide, ou un sel du peptide ou du dérivé : (a) un peptide comprenant une séquence d'acides aminés représentée par l'une quelconque des SEQ ID NO : 10, 4, 12 et 6 ; et (b) un peptide comprenant une séquence d'acides aminés représentée par l'une quelconque des SEQ ID NO : 16, 18, 20 et 22.
(JA) 本発明は、上皮及び内皮損傷、特に上皮及び内皮の微小損傷の治療剤等を提供する。本発明に係る治療剤は、例えば、下記(a)又は(b)などのペプチド、その誘導体あるいはこれらの塩を含むことを特徴とするものである。(a) 配列番号10、4、12及び6のいずれかに示されるアミノ酸配列を含むペプチド。(b) 配列番号16、18、20及び22のいずれかに示されるアミノ酸配列を含むペプチド。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)