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1. (WO2013162065) METHOD FOR PRODUCING 5-(DIFLUOROMETHYL)PYRAZINE-2-CARBOXILIC ACID AND PRODUCTION INTERMEDIATE THEREOF

Pub. No.:    WO/2013/162065    International Application No.:    PCT/JP2013/062863
Publication Date: Fri Nov 01 00:59:59 CET 2013 International Filing Date: Fri Apr 26 01:59:59 CEST 2013
IPC: C07D 241/24
C07B 61/00
Applicants: EISAI R&D MANAGEMENT CO., LTD.
Inventors: YOSHIZAWA, Kazuhiro
OMORI, Masayuki
WATANABE, Yuzo
NAGAI, Mitsuo
TAKAHASHI, Masabumi
FANG, Francis, G.
Title: METHOD FOR PRODUCING 5-(DIFLUOROMETHYL)PYRAZINE-2-CARBOXILIC ACID AND PRODUCTION INTERMEDIATE THEREOF
Abstract:
5-(Difluoromethyl)pyrazine-2-carboxilic acid, which is a raw material for the construction of 5-(difluoromethyl)pyrazine-2-carboxamide, which is a common partial structural motif of the compound having an A production inhibitory action or a BACE1 inhibitory action, can be industrially advantageously produced by decarboxylating 5-[carboxy(difluoro)methyl]pyrazine-2-carboxylic acid, which is obtainable from 5-chloropyrazine-2-carboxylate.