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1. (WO2013162065) METHOD FOR PRODUCING 5-(DIFLUOROMETHYL)PYRAZINE-2-CARBOXILIC ACID AND PRODUCTION INTERMEDIATE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/162065    International Application No.:    PCT/JP2013/062863
Publication Date: 31.10.2013 International Filing Date: 25.04.2013
IPC:
C07D 241/24 (2006.01), C07B 61/00 (2006.01)
Applicants: EISAI R&D MANAGEMENT CO., LTD. [JP/JP]; 6-10, Koishikawa 4-chome, Bunkyo-ku, Tokyo 1128088 (JP)
Inventors: YOSHIZAWA, Kazuhiro; (JP).
OMORI, Masayuki; (JP).
WATANABE, Yuzo; (JP).
NAGAI, Mitsuo; (JP).
TAKAHASHI, Masabumi; (JP).
FANG, Francis, G.; (US)
Agent: ASAMURA PATENT OFFICE, P.C.; Tennoz Central Tower, 2-2-24 Higashi-Shinagawa, Shinagawa-ku, Tokyo 1408776 (JP)
Priority Data:
61/639,362 27.04.2012 US
Title (EN) METHOD FOR PRODUCING 5-(DIFLUOROMETHYL)PYRAZINE-2-CARBOXILIC ACID AND PRODUCTION INTERMEDIATE THEREOF
(FR) PROCÉDÉ DE PRODUCTION D'ACIDE 5-(DIFLUOROMÉTHYL)PYRAZINE-2-CARBOXYLIQUE ET D'UN INTERMÉDIAIRE POUR SA PRODUCTION
Abstract: front page image
(EN)5-(Difluoromethyl)pyrazine-2-carboxilic acid, which is a raw material for the construction of 5-(difluoromethyl)pyrazine-2-carboxamide, which is a common partial structural motif of the compound having an A production inhibitory action or a BACE1 inhibitory action, can be industrially advantageously produced by decarboxylating 5-[carboxy(difluoro)methyl]pyrazine-2-carboxylic acid, which is obtainable from 5-chloropyrazine-2-carboxylate.
(FR)Cette invention concerne un acide 5-(difluorométhyl)pyrazine-2- carboxylique, qui est un matériau de départ pour la production du 5-(difluorométhyl)pyrazine-2-carboxamide, qui est un motif structural partiel commun du composé ayant une action inhibitrice de production ou une action inhibitrice de BACE1, qui peut être avantageusement produit à l'échelle industrielle par décarboxylation d'un acide 5-[carboxy- (difluoro)méthyl]-pyrazine-2-carboxylique, qui peut être obtenu à partir de 5-chloropyrazine-2-carboxylate.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)