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1. WO2013162057 - CELL PREPARATION CONTAINING MYOCARDIUM-COMMITTED CELL

Publication Number WO/2013/162057
Publication Date 31.10.2013
International Application No. PCT/JP2013/062798
International Filing Date 25.04.2013
Chapter 2 Demand Filed 25.02.2014
IPC
C12N 5/07 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
A61K 35/36 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
A61L 27/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
A61P 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
C12N 5/077 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
077Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
CPC
A61K 35/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
A61K 35/34
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
34Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
A61L 2300/204
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2300Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
20containing or releasing organic materials
204with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
A61L 2430/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2430Materials or treatment for tissue regeneration
20for reconstruction of the heart, e.g. heart valves
A61L 2430/30
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2430Materials or treatment for tissue regeneration
30for muscle reconstruction
A61L 27/3834
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
36containing ingredients of undetermined constitution or reaction products thereof ; , e.g. transplant tissue, natural bone, extracellular matrix
38containing added animal cells
3804characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
3834Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
Applicants
  • 独立行政法人理化学研究所 RIKEN [JP]/[JP]
  • 松山 晃文 MATSUYAMA, Akifumi [JP]/[JP]
Inventors
  • 松山 晃文 MATSUYAMA, Akifumi
  • 大倉 華雪 OKURA, Hanayuki
Agents
  • 平木 祐輔 HIRAKI, Yusuke
Priority Data
2012-10036225.04.2012JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) CELL PREPARATION CONTAINING MYOCARDIUM-COMMITTED CELL
(FR) PRÉPARATION CELLULAIRE CONTENANT UNE CELLULE ENGAGÉE DU MYOCARDE
(JA) 心筋指向性細胞を含む細胞製剤
Abstract
(EN)
The present invention relates to a method for producing a cell mass which contains a myocardium-committed cell capable of being differentiated and adhered as a myocardial cell under a myocardial tissue environment. Specifically, the method is characterized by culturing an adipose-tissue-originated multipotent progenitor cell in the presence of a polyamine. The present invention also relates to: a cell mass which contains a myocardium-committed cell; and a cell preparation or a cell sheet, which contains the cell mass. The present invention further relates to a method for treating a heart disease, which comprises administering the cell mass to a subject.
(FR)
La présente invention concerne un procédé de production d'une masse cellulaire qui contient une cellule engagée du myocarde pouvant se différencier et adhérer comme une cellule myocardique dans un environnement tissulaire myocardique. En particulier, le procédé est caractérisé par la culture d'une cellule progéniteur multipotente provenant de tissu adipeux en présence d'une polyamine. La présente invention concerne également : une masse cellulaire qui contient une cellule engagée de myocarde; et une préparation cellulaire ou une feuille cellulaire, qui contient la masse cellulaire. La présente invention concerne en outre un procédé de traitement d'une maladie cardiaque qui comprend l'administration de la masse cellulaire à un sujet.
(JA)
 本発明は、心筋組織環境下で心筋細胞として分化生着する心筋指向性細胞を含む細胞集団を製造する方法に関し、具体的には、この方法は、脂肪組織由来多系統前駆細胞をポリアミンの存在下で培養することを特徴とする。本発明はまた、心筋指向性細胞を含む細胞集団、該細胞集団を含む細胞製剤、又は細胞シートに関する。本発明はさらに、該細胞集団を被験体に投与することを含む心疾患の治療方法に関する。
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