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1. (WO2013161980) CYCLOHEXANEDIAMIDE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/161980    International Application No.:    PCT/JP2013/062335
Publication Date: 31.10.2013 International Filing Date: 26.04.2013
IPC:
C07C 255/64 (2006.01), A61K 31/165 (2006.01), A61K 31/275 (2006.01), A61P 9/12 (2006.01), A61P 13/12 (2006.01), A61P 43/00 (2006.01), C07C 237/24 (2006.01), C07C 311/06 (2006.01)
Applicants: TORAY INDUSTRIES, INC. [JP/JP]; 1-1, Nihonbashi-Muromachi 2-chome, Chuo-ku, Tokyo 1038666 (JP)
Inventors: KUROSAWA, Satoshi; (JP).
NISHIMURA, Yutaka; (JP).
KATO, Yuko; (JP).
FUCHI, Nobuhiro; (JP).
AOKI, Takumi; (JP).
YAMADA, Masateru; (JP).
YAMADA, Naohiro; (JP)
Priority Data:
2012-102764 27.04.2012 JP
Title (EN) CYCLOHEXANEDIAMIDE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES
(FR) DÉRIVÉ DE CYCLOHEXANEDIAMIDE ET SON UTILISATION À DES FINS MÉDICALES
(JA) シクロヘキサンジアミド誘導体及びその医薬用途
Abstract: front page image
(EN)The purpose of the present invention is to provide: a compound having an sEH-inhibiting activity; and a medicinal agent which has an sEH-inhibiting activity and therefore can exhibit a therapeutic effect and a prophylactic effect on chronic kidney diseases and pulmonary hypertension. The present invention provides a cyclohexanediamide derivative represented by chemical formula (1).
(FR)L'invention concerne un composé et un agent médicinal présentant tous deux une activité d'inhibition de sEH, et pouvant ainsi avoir un effet thérapeutique et un effet prophylactique sur les maladies rénales chroniques et l'hypertension pulmonaire. L'invention concerne également un dérivé de cyclohexanediamide représenté par la formule (1).
(JA) 本発明は、sEH阻害活性を示す化合物を提供するとともに、sEH阻害作用に基づき慢性腎臓病及び肺高血圧症に対する治療効果及び予防効果を発揮する医薬を提供することを目的としている。本発明は、下記の化学式に代表されるシクロヘキサンジアミド誘導体を提供する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)