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1. (WO2013161933) DEUTERATED NITROGEN-CONTAINING HETEROCYCLIC CARBOXAMIDE DERIVATIVE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/161933    International Application No.:    PCT/JP2013/062192
Publication Date: 31.10.2013 International Filing Date: 25.04.2013
IPC:
C07D 241/24 (2006.01), A61K 31/4965 (2006.01), A61P 31/14 (2006.01), A61P 31/16 (2006.01), A61P 31/20 (2006.01)
Applicants: TOYAMA CHEMICAL CO., LTD. [JP/JP]; 2-5, Nishishinjuku 3-chome, Shinjuku-ku Tokyo 1600023 (JP) (For All Designated States Except US).
TSUTSUI, Yasuhiro [JP/JP]; (JP) (US only).
ANZAI, Shuzo [JP/JP]; (JP) (US only)
Inventors: TSUTSUI, Yasuhiro; (JP).
ANZAI, Shuzo; (JP)
Priority Data:
2012-101579 26.04.2012 JP
Title (EN) DEUTERATED NITROGEN-CONTAINING HETEROCYCLIC CARBOXAMIDE DERIVATIVE
(FR) DÉRIVÉ DE CARBOXAMIDE HÉTÉROCYCLIQUE DEUTÉRÉ CONTENANT DE L'AZOTE
(JA) 重水素化含窒素複素環カルボキサミド誘導体
Abstract: front page image
(EN)This deuterated nitrogen-containing heterocyclic carboxamide derivative represented by general formula (1) (in the formula, D represents a deuterium atom, and R represents a hydrogen atom or deuterium atom), or a salt thereof, exhibits excellent pharmacokinetics, such as maintenance of a high blood concentration and/or increase in AUC, and is useful as an antiviral agent.
(FR)L'invention concerne un dérivé de carboxamide hétérocyclique deutéré contenant de l'azote représenté par la formule générale (1) (dans la formule, D représente un atome de deutérium, et R représente un atome d'hydrogène ou un atome de deutérium), ou un sel de celui-ci, qui manifeste une excellente pharmacocinétique, telle que le maintien d'une concentration sanguine élevée et/ou un accroissement de la valeur AUC, et qui est utile à titre d'agent antiviral.
(JA)一般式[1]「式中、Dは、重水素原子を;Rは、水素原子または重水素原子を示す。」で表される重水素化含窒素複素環カルボキサミド誘導体またはその塩は、高い血中濃度の維持および/またはAUCの増加などの優れた体内動態等を示し、抗ウイルス剤として有用である。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)