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1. (WO2013161816) AMINE COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/161816    International Application No.:    PCT/JP2013/061922
Publication Date: 31.10.2013 International Filing Date: 23.04.2013
IPC:
C07C 225/18 (2006.01), A61K 31/137 (2006.01), A61K 31/352 (2006.01), A61K 31/382 (2006.01), A61K 31/665 (2006.01), A61K 31/67 (2006.01), A61P 3/10 (2006.01), A61P 11/02 (2006.01), A61P 11/06 (2006.01), A61P 13/12 (2006.01), A61P 17/00 (2006.01), A61P 17/06 (2006.01), A61P 19/02 (2006.01), A61P 25/00 (2006.01), A61P 29/00 (2006.01), A61P 37/02 (2006.01), A61P 37/06 (2006.01), A61P 37/08 (2006.01), C07D 311/86 (2006.01), C07D 335/16 (2006.01), C07D 409/12 (2006.01), C07F 9/655 (2006.01), C07F 9/6553 (2006.01)
Applicants: MITSUBISHI TANABE PHARMA CORPORATION [JP/JP]; 2-6-18, Kitahama, Chuo-ku, Osaka-shi, Osaka 5418505 (JP)
Inventors: HAMADA, Maiko; (JP).
TASHIRO, Kaoru; (JP).
SAKASHITA, Hiroshi; (JP).
KIUCHI, Masatoshi; (JP).
TAKEDA, Shuzo; (JP).
ADACHI, Kunitomo; (JP)
Agent: TAKASHIMA, Hajime; Meiji Yasuda Seimei Osaka Midosuji Bldg., 1-1, Fushimimachi 4-chome, Chuo-ku, Osaka-shi, Osaka 5410044 (JP)
Priority Data:
2012-097741 23.04.2012 JP
Title (EN) AMINE COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES
(FR) COMPOSÉ AMINE ET SON UTILISATION À DES FINS MÉDICALES
(JA) アミン化合物及びその医薬用途
Abstract: front page image
(EN)The present invention provides a compound represented by general formula (I) [wherein each symbol is as defined in the description], which has an excellent peripheral blood lymphocyte-reducing activity and is useful for the treatment or prevention of autoimmune diseases, the prevention or inhibition of resistance or acute or chronic rejection of an organ or a tissue against transplantation, the treatment or prevention of graft-versus-host (GvH) disease caused by bone marrow transplantation, or the treatment or prevention of allergic diseases.
(FR)La présente invention concerne un composé représenté par la formule générale (I) [dans laquelle chaque symbole est tel que défini dans la description] qui a une excellente activité de réduction des lymphocytes de sang périphérique et est utile pour le traitement ou la prévention de maladies auto-immunes, la prévention ou l'inhibition de la résistance ou du rejet aigu ou chronique d'un organe ou d'un tissu à l'encontre d'une transplantation, le traitement ou la prévention de la maladie du greffon contre l'hôte (GvH) provoquée par une transplantation de moelle osseuse, ou le traitement ou la prévention de maladies allergiques.
(JA)本発明は、優れた末梢血リンパ球減少作用を有し、自己免疫疾患の治療又は予防、器官又は組織の移植に対する抵抗又は急性拒絶反応若しくは慢性拒絶反応の予防又は抑制、骨髄移植による移植片対宿主(GvH)病の治療又は予防、あるいはアレルギー性疾患の治療又は予防に有用な下記一般式(I):[式中の各記号は、明細書に記載のとおりである。]で表される化合物を提供する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)