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1. (WO2013161805) METHOD FOR PRODUCING STARCH GRANULES, AND ORALLY DISINTEGRATING TABLET

Pub. No.:    WO/2013/161805    International Application No.:    PCT/JP2013/061900
Publication Date: Fri Nov 01 00:59:59 CET 2013 International Filing Date: Wed Apr 24 01:59:59 CEST 2013
IPC: C08J 3/12
A61K 47/36
C08B 30/06
C08B 30/12
Applicants: JAPAN CORN STARCH CO., LTD
日本コーンスターチ株式会社
Inventors: UMEZAKI, Masao
梅崎 真生
MURASE, Hiroshige
村瀬 博重
UNO, Toshio
宇野 敏夫
NIWA, Toshiyuki
丹羽 敏幸
Title: METHOD FOR PRODUCING STARCH GRANULES, AND ORALLY DISINTEGRATING TABLET
Abstract:
A method for producing starch granules suitable as an excipient for an orally disintegrating tablet. A paste is sprayed in small amounts while β-starch is being fluidized using an air-fluidized bed to carry out fluidized bed granulation. Thereafter, fluidized bed drying is carried out at the gelatinization temperature of the β-starch or higher. This results in starch granules having a high degree of gelatinization in comparison with the amount of gelatinized starch adhered to the β-starch by the spraying of the paste. These starch granules alone impart an adequate oral disintegration performance and breaking strength to the tablet. Consequently, in instances of use as an excipient for tableting of orally disintegrating tablets, another auxiliary excipient such as crystalline cellulose or a sugar or the like need not be added.