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1. (WO2013161751) COMPOSITE PARTICLES AND CELL PREPARATION PREPARED USING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/161751 International Application No.: PCT/JP2013/061758
Publication Date: 31.10.2013 International Filing Date: 22.04.2013
IPC:
C08J 3/12 (2006.01) ,A61K 9/16 (2006.01) ,A61K 35/12 (2006.01) ,A61K 35/28 (2006.01) ,A61K 47/02 (2006.01) ,A61K 47/34 (2006.01) ,A61L 27/00 (2006.01) ,A61P 9/00 (2006.01) ,A61P 43/00 (2006.01) ,C08K 3/32 (2006.01) ,C08L 67/04 (2006.01)
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
J
WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H142
3
Processes of treating or compounding macromolecular substances
12
Powdering or granulating
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
16
Agglomerates; Granulates; Microbeadlets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
28
Marrow; Spleen
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
02
Inorganic compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
34
Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
K
USE OF INORGANIC OR NON-MACROMOLECULAR ORGANIC SUBSTANCES AS COMPOUNDING INGREDIENTS
3
Use of inorganic ingredients
32
Phosphorus-containing compounds
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
L
COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
67
Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
04
Polyesters derived from hydroxy carboxylic acids, e.g. lactones
Applicants:
学校法人近畿大学 KINKI UNIVERSITY [JP/JP]; 大阪府東大阪市小若江3丁目4番1号 3-4-1, Kowakae, Higashiosaka-shi, Osaka 5778502, JP
公立大学法人大阪市立大学 OSAKA CITY UNIVERSITY [JP/JP]; 大阪府大阪市住吉区杉本3丁目3番138号 3-3-138, Sugimoto, Sumiyoshi-ku, Osaka-shi, Osaka 5588585, JP
学校法人常翔学園 JOSHO GAKUEN [JP/JP]; 大阪府大阪市旭区大宮五丁目16番1号 5-16-1, Omiya, Asahi-ku, Osaka-shi, Osaka 5358585, JP
株式会社ソフセラ SOFSERA CORPORATION [JP/JP]; 東京都新宿区新宿6-7-1-314 エルプリメント新宿3F 3rd Floor, ELPULIMENTO Shinjuku, 6-7-1-314, Shinjuku, Shinjuku-ku, Tokyo 1600022, JP
グンゼ株式会社 GUNZE LIMITED [JP/JP]; 京都府綾部市青野町膳所1番地 1, Zeze, Aono-cho, Ayabe-shi, Kyoto 6238511, JP
Inventors:
古薗 勉 FURUZONO, Tsutomu; JP
稲葉 雅章 INABA, Masaaki; JP
福本 真也 FUKUMOTO, Shinya; JP
三間 洋平 MIMA, Yohei; JP
藤井 秀司 FUJII, Shuji; JP
小粥 康充 KOGAYU, Yasumitsu; JP
松田 晶二郎 MATSUDA, Shojiro; JP
高森 秀樹 TAKAMORI, Hideki; JP
Agent:
山田 威一郎 YAMADA, Iichiro; 大阪府大阪市北区中之島6-2-40 中之島インテス21階 21st Floor, Nakanoshima Intes Bldg., 6-2-40, Nakanoshima, Kita-ku, Osaka-shi Osaka 5300005, JP
Priority Data:
2012-10118926.04.2012JP
Title (EN) COMPOSITE PARTICLES AND CELL PREPARATION PREPARED USING SAME
(FR) PARTICULES COMPOSITES ET PRÉPARATION DE CELLULES OBTENUE À L'AIDE DE CELLES-CI
(JA) 複合粒子及びそれを用いた細胞製剤
Abstract:
(EN) The main purpose of the present invention is to provide: composite particles which can hold transplanted cells thereon satisfactorily for a period of time until the effect of the cells is developed; and a cell preparation comprising the composite particles and cells supported on the composite particles. The purpose can be achieved by composite particles each of which comprises inorganic particles adsorbed on the surface of a particle comprising an L-lactide-ε-caprolactone copolymer, wherein the constitutional molar ratio of L-lactide to an ε-caprolactone copolymer in the copolymer is approximately 75/25. The present invention also provides a cell preparation comprising cell-supported composite particles, which comprises cell-supported composite particles produced by supporting cells on the above-mentioned composite particles.
(FR) La présente invention a pour but principal de proposer : des particules composites qui peuvent maintenir des cellules transplantées sur celles-ci de façon satisfaisante pendant une période de temps jusqu'à ce que l'effet des cellules soit développé; et une préparation de cellules comprenant les particules composites et des cellules supportées sur les particules composites. Le but peut être atteint par des particules composites dont chacune comprend des particules inorganiques adsorbées sur la surface d'une particule comprenant un copolymère L-lactide-ε-caprolactone, le rapport molaire structural de L-lactide à un copolymère d'ε-caprolactone dans le copolymère étant d'approximativement 75/25. La présente invention concerne également une préparation de cellules comprenant des particules composites à cellules supportées, qui comprend des particules composites à cellules supportées que l'on a obtenues en amenant des cellules à être supportées sur les particules composites mentionnées ci-dessus.
(JA)  本発明は、移植細胞による効果が得られるまでの期間、十分に細胞を保持することが可能な複合粒子、及び該複合粒子に細胞を担持させてなる細胞製剤を提供することを主な課題とする。 L-ラクチド-ε-カプロラクトン共重合体からなる粒子表面に無機粒子を吸着させてなる複合粒子であって、前記共重合体におけるL-ラクチドとε-カプロラクトン共重合体の構成モル比が略75/25である複合粒子により実現される。更に、本発明は、前記複合粒子に細胞を担持させてなる細胞担持複合粒子を含む、細胞担持複合粒子を含む細胞製剤を提供する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)