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1. WO2013161675 - METHOD FOR STABILIZING SERUM OR PLASMA ASCORBIC ACID

Publication Number WO/2013/161675
Publication Date 31.10.2013
International Application No. PCT/JP2013/061528
International Filing Date 18.04.2013
IPC
G01N 33/48 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
C12Q 1/26 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
26involving oxidoreductase
C12Q 1/28 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
26involving oxidoreductase
28involving peroxidase
CPC
C12Q 1/26
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
26involving oxidoreductase
G01N 2333/90235
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
90Enzymes; Proenzymes
902Oxidoreductases (1.)
90219acting on diphenols and related substances as donors (1.10)
90222with oxygen as acceptor (1.10.3) in general
90225with a definite EC number (1.10.3.-)
90235Ascorbate oxidase (1.10.3.3)
G01N 33/49
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
483Physical analysis of biological material
487of liquid biological material
49Blood
G01N 33/82
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
82involving vitamins ; or their receptors
Applicants
  • 協和メデックス株式会社 KYOWA MEDEX CO., LTD. [JP]/[JP]
Inventors
  • 佐々木 一彦 SASAKI, Kazuhiko
  • 青山 典仁 AOYAMA, Norihito
Priority Data
2012-10325627.04.2012JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) METHOD FOR STABILIZING SERUM OR PLASMA ASCORBIC ACID
(FR) PROCÉDÉ DE STABILISATION DE L'ACIDE ASCORBIQUE SÉRIQUE OU PLASMATIQUE
(JA) 血清又は血漿中のアスコルビン酸の安定化方法
Abstract
(EN)
Provided are a method for stabilizing serum or plasma ascorbic acid, and a method for storing serum or plasma ascorbic acid. A method for stabilizing serum or plasma ascorbic acid, the method being characterized by comprising storing serum or plasma ascorbic acid in the presence of blood cells in an aqueous vehicle having an osmotic pressure at which blood cells in whole blood are not ruptured; and a method for storing serum or plasma ascorbic acid, the method being characterized by comprising storing serum or plasma ascorbic acid in the presence of blood cells in an aqueous vehicle having an osmotic pressure at which blood cells in whole blood are not ruptured. This method for stabilizing serum or plasma ascorbic acid and this method for storing serum or plasma ascorbic acid are useful for clinical diagnoses.
(FR)
La présente invention concerne un procédé de stabilisation de l'acide ascorbique sérique ou plasmatique et un procédé de stockage de l'acide ascorbique sérique ou plasmatique. L'invention concerne un procédé de stabilisation de l'acide ascorbique sérique ou plasmatique, le procédé étant caractérisé en ce qu'il consiste à stocker de l'acide ascorbique sérique ou plasmatique en présence de cellules sanguines dans un véhicule aqueux ayant une pression osmotique à laquelle les cellules sanguines dans le sang total ne se rompent pas ; et un procédé de stockage de l'acide ascorbique sérique ou plasmatique, le procédé étant caractérisé en ce qu'il consiste à stocker l'acide ascorbique sérique ou plasmatique en présence de cellules sanguines dans un véhicule aqueux ayant une pression osmotique à laquelle les cellules sanguines dans le sang total ne se rompent pas. Ce procédé de stabilisation de l'acide ascorbique sérique ou plasmatique et ce procédé de stockage de l'acide ascorbique sérique ou plasmatique sont utiles pour des diagnostiques cliniques.
(JA)
 血清又は血漿中のアスコルビン酸の安定化方法、及び、血清又は血漿中のアスコルビン酸の保存方法を提供する。 血清又は血漿中のアスコルビン酸を、全血中の血球を溶血させない浸透圧を有する水性媒体中に血球の共存下で保存することを特徴とする、血漿又は血清中のアスコルビン酸の安定化方法;血清又は血漿中のアスコルビン酸を、全血中の血球を溶血させない浸透圧を有する水性媒体中に血球の共存下で保存することを特徴とする、血漿又は血清中のアスコルビン酸の保存方法。 本発明の血清又は血漿中のアスコルビン酸の安定化方法、及び、血清又は血漿中のアスコルビン酸の保存方法は、臨床診断に有用である。
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