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1. (WO2013160914) NOVEL SYNERGISTIC COMPOSITION COMPRISING OF A CAROTENOID, SERM AND AN AMINO ACID DERIVATIVE THEREOF

Pub. No.:    WO/2013/160914    International Application No.:    PCT/IN2013/000277
Publication Date: Fri Nov 01 00:59:59 CET 2013 International Filing Date: Wed Apr 24 01:59:59 CEST 2013
IPC: A61K 31/122
A61K 31/138
A61K 31/198
A61P 15/08
Applicants: RAMANAN, Ezhil Arasan
Inventors: RAMANAN, Ezhil Arasan
Title: NOVEL SYNERGISTIC COMPOSITION COMPRISING OF A CAROTENOID, SERM AND AN AMINO ACID DERIVATIVE THEREOF
Abstract:
The present invention refers to a combination for ovulation induction and infertility in women. The present invention particularly relates to a synergistic composition comprising a carotenoid, and an antioxidant over and above an agent that induces ovulation. The synergistic composition for inducing ovulation comprising a combination of antioxidants with a carotenoid and a selective estrogen receptor modulator (SERM) or an aromatase inhibitor. The present invention preferably refers to Astaxanthin and N acetyl cysteine added to the regular treatment of a selective estrogen receptor modulator and an aromatase inhibitor. More specifically, the invention relates to the use of such synergistic composition for inducing ovulation thereby increasing the pregnancy outcome with the complete management of infertility in particular in females who are disposed and predisposed to amenorrhea, hormonal imbalance, irregular menstruation, hyperinsulinemia related manifestations, obesity, PCOS, endometriosis and other factors.