The present invention refers to a combination for ovulation induction and infertility in women. The present invention particularly relates to a synergistic composition comprising a carotenoid, and an antioxidant over and above an agent that induces ovulation. The synergistic composition for inducing ovulation comprising a combination of antioxidants with a carotenoid and a selective estrogen receptor modulator (SERM) or an aromatase inhibitor. The present invention preferably refers to Astaxanthin and N acetyl cysteine added to the regular treatment of a selective estrogen receptor modulator and an aromatase inhibitor. More specifically, the invention relates to the use of such synergistic composition for inducing ovulation thereby increasing the pregnancy outcome with the complete management of infertility in particular in females who are disposed and predisposed to amenorrhea, hormonal imbalance, irregular menstruation, hyperinsulinemia related manifestations, obesity, PCOS, endometriosis and other factors.