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1. (WO2013160913) ROTAVIRUS VACCINE COMPOSITIONS AND PROCESS FOR PREPARING THE SAME

Pub. No.:    WO/2013/160913    International Application No.:    PCT/IN2013/000272
Publication Date: Fri Nov 01 00:59:59 CET 2013 International Filing Date: Wed Apr 24 01:59:59 CEST 2013
IPC: A61K 39/15
A61P 31/14
Applicants: BHARAT BIOTECH INTERNATIONAL LIMITED
VADREVU, Krishna Mohan
PRASAD, Sai Devarajulu
Inventors: VADREVU, Krishna Mohan
PRASAD, Sai Devarajulu
Title: ROTAVIRUS VACCINE COMPOSITIONS AND PROCESS FOR PREPARING THE SAME
Abstract:
Invention provides rotavirus vaccine compositions comprising rotavirus antigens, stabilizers and buffers. The buffers in the invention are pre-mixed in the rotavirus vaccine compositions to neutralize the high acidic pH of the stomach without, requiring separate administration of an antacid before vaccine administration. Vaccine compositions with buffers of the invention are stable liquid rotavirus vaccine formulations for oral administration.