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1. (WO2013160431) ANTIBACTERIAL QUINOLINE DERIVATIVES

Pub. No.:    WO/2013/160431    International Application No.:    PCT/EP2013/058697
Publication Date: Fri Nov 01 00:59:59 CET 2013 International Filing Date: Sat Apr 27 01:59:59 CEST 2013
IPC: C07D 401/06
A61K 31/4709
A61P 31/06
C07D 401/14
Applicants: JANSSEN PHARMACEUTICA NV
Inventors: GUILLEMONT, Jerôme, Emile, Georges
MOTTE, Magali, Madeleine, Simone
LANÇOIS, David, Francis, Alain
THOMAS, Sébastien, Robert, Gaston
BALEMANS, Wendy, Mia, Albert
Title: ANTIBACTERIAL QUINOLINE DERIVATIVES
Abstract:
The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or Formula (Ib): including any stereochemically isomeric form thereof, a pharmaceutically acceptable salt thereof, a N-oxide form thereof or a solvate thereof. The claimed compounds are useful for the treatment of a bacterial infection. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of a bacterial infection and a process for preparing the claimed compounds.