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1. (WO2013160365) STEREOSELECTIVE HYDROXYLATION OF BENZENES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/160365 International Application No.: PCT/EP2013/058525
Publication Date: 31.10.2013 International Filing Date: 24.04.2013
IPC:
C12P 33/06 (2006.01) ,C12N 9/00 (2006.01) ,C12N 9/02 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
33
Preparation of steroids
06
Hydroxylating
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
02
Oxidoreductases (1.), e.g. luciferase
Applicants:
DSM IP ASSETS B.V. [NL/NL]; Patent Department Het Overloon 1 NL-6411 The Heerlen, NL
Inventors:
SCHÜRMANN, Martin; NL
BONRATH, Werner; CH
DENNIG, Alexander; DE
MARIENHAGEN, Jan; DE
SCHWANENBERG, Ulrich; BE
RUFF, Anna Joelle; BE
Agent:
SEIBEL THOMSEN, Nadja; DSM Nutritional Products Ltd Wurmisweg 576 CH-4303 Kaiseraugst, CH
Priority Data:
12165386.924.04.2012EP
Title (EN) STEREOSELECTIVE HYDROXYLATION OF BENZENES
(FR) HYDROXYLATION STÉRÉOSÉLECTIVE DES BENZÈNES
Abstract:
(EN) The present invention relates to novel cytochrome P450 monooxygenase with modified (higher) substrate selectivity and/or (re)activity towards aromatic hydroxylation of benzenes. In particular, the invention provides nucleic acid sequences coding for the novel enzymes, expression constructs and vectors comprising these sequences, transformed microorganisms expressing these novel enzymes, and processes for the stereoselective hydroxylation of substituted benzenes useful as building blocks in vitamin E synthesis.
(FR) Cette invention concerne une nouvelle cytochrome P450 monooxygénase ayant une sélectivité de substrat et/ou une (ré)activité vis-à-vis de l'hydroxylation des benzènes modifiées (supérieures). En particulier, l'invention concerne des séquences d'acides nucléiques codant pour les nouvelles enzymes, des produits et recombinaison et des vecteurs d'expression les contenant, des micro-organismes transformés exprimant ces nouvelles enzymes, et des procédés d'hydroxylation stéréosélective de benzènes substitués utiles à titre d'éléments structuraux dans la synthèse de la vitamine E.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)