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1. (WO2013160124) FEEDBACK-RESISTANT ALPHA-ISOPROPYLMALATE SYNTHASES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/160124 International Application No.: PCT/EP2013/057660
Publication Date: 31.10.2013 International Filing Date: 12.04.2013
IPC:
C12N 9/10 (2006.01) ,C12P 13/06 (2006.01)
Applicants: GERSTMEIR, Robert[DE/DE]; DE (US)
WIEGRÄBE, Iris[DE/DE]; DE (US)
EVONIK INDUSTRIES AG[DE/DE]; Rellinghauser Straße 1 - 11 45128 Essen, DE (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
Inventors: GERSTMEIR, Robert; DE
WIEGRÄBE, Iris; DE
Priority Data:
10 2012 207 097.427.04.2012DE
Title (EN) FEEDBACK-RESISTANT ALPHA-ISOPROPYLMALATE SYNTHASES
(FR) ALOHA-ISOPROPYLMALATE SYNTHASES RÉSISTANT À LA RÉTROACTION
Abstract:
(EN) The invention relates to an isolated nucleotide sequence encoding an amino acid sequence that is at least ≥ 90%, ≥ 92%, ≥ 94%, ≥ 96%, ≥ 97%, ≥ 98%, ≥ 99% or 100%, preferably ≥ 97%, particularly preferably ≥ 98%, very particularly preferably ≥ 99%, and extremely preferably 0%, identical to the amino acid sequence of SEQ ID NO:2, wherein SEQ ID NO:2, at position 553, or at a corresponding position of the amino acid sequence, has a proteinogenic amino acid other than L-tyrosine, to a microorganism comprising the nucleotide sequence and also to a process for producing fine chemicals using this microorganism.
(FR) L'invention concerne une séquence nucléotidique isolée codant pour une séquence d'acides aminés qui est au moins identique à ≥ 90%, ≥92%, ≥ 94%, ≥ 96%, ≥ 97%, ≥ 98%, ≥ 99% ou 100%, de préférence ≥ 97%, de façon particulièrement préférée ≥ 98%, de façon tout particulièrement préférée ≥ 99%, et de façon extrêmement préférée 100%, à la séquence d'acides aminés de SEQ ID NO:2, dans laquelle SEQ ID NO:2,à la position 553 ou à une position correspondante de la séquence d'acides aminés, a un acide aminé protéinogène autre que la L-tyrosine; l'invention concerne également un microorganisme comprenant la séquence nucléotidique ainsi qu'un procédé de fabrication de produits chimiques fins à l'aide de ce microorganisme.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)