WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2013159224) 2-CARBAMO(THIO)YL-1,3- DIOXOPROPYL DERIVATIVES IN CANCER THERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/159224    International Application No.:    PCT/CA2013/050310
Publication Date: 31.10.2013 International Filing Date: 22.04.2013
IPC:
C07D 487/04 (2006.01), A61K 31/505 (2006.01), A61K 31/519 (2006.01), A61P 35/00 (2006.01), C07C 327/48 (2006.01), C07D 231/32 (2006.01), C07D 239/60 (2006.01), C07D 309/38 (2006.01), C07D 335/02 (2006.01)
Applicants: CHEE, Gaik-Lean [CA/CA]; (CA).
BREWER, A. David [CA/CA]; (CA).
HASINOFF, Brian B. [CA/CA]; (CA).
UNIVERSITY OF MANITOBA [CA/CA]; 631 Drake Building 181 Freedman Crescent Winnipeg, Manitoba R3T 5V4 (CA).
CHEMTURA [US/US]; 199 Benson Road Middlebury, Connecticut 06749 (US)
Inventors: CHEE, Gaik-Lean; (CA).
BREWER, A. David; (CA).
HASINOFF, Brian B.; (CA)
Agent: ADE & COMPANY INC.; 2157 Henderson Highway Winnipeg, Manitoba R2G 1P9 (CA)
Priority Data:
61/638,176 25.04.2012 US
Title (EN) 2-CARBAMO(THIO)YL-1,3- DIOXOPROPYL DERIVATIVES IN CANCER THERAPY
(FR) DÉRIVÉS 2-CARBAMO(THIO)YL-1,3-DIOXOPROPYLÉS EN THÉRAPIE DU CANCER
Abstract: front page image
(EN)Certain 2-carbamo(thio)yl-1,3-dioxopropyl derivatives, or the tautomers and pharmacologically acceptable addition salts thereof are found to be toxic to cancer cells, in part, by inhibiting DNA topoisomerase II enzyme making them candidates for pharmaceutical use as anticancer agents.
(FR)Certains dérivés 2-carbamo(thio)yl-1,3-dioxopropylés, ou les tautomères et sels d'addition pharamacologiquement acceptables de ceux-ci sont trouvés comme étant toxiques vis-à-vis de cellules cancéreuses, en partie, par l'inhibition de l'enzyme ADN topoisomérase II, faisant de ceux-ci des candidats pour une utilisation pharmaceutique comme agents anti-cancéreux.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)