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1. (WO2013159109) MODULATION OF HEPATITIS B VIRUS (HBV) EXPRESSION
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/159109 International Application No.: PCT/US2013/037642
Publication Date: 24.10.2013 International Filing Date: 22.04.2013
IPC:
C12N 15/85 (2006.01) ,A61K 48/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applicants: ISIS PHARMACEUTICALS, INC.[US/US]; 2855 Gazelle Court Carlsbad, CA 92010, US
Inventors: SWAYZE, Eric, E.; US
Agent: TUNG, Jeffrey, J.; ISIS Pharmaceuticals, Inc. 2855 Gazelle Court Carlsbad, CA 92010, US
Priority Data:
61/636,54420.04.2012US
Title (EN) MODULATION OF HEPATITIS B VIRUS (HBV) EXPRESSION
(FR) MODULATION DE L'EXPRESSION DU VIRUS DE L'HÉPATITE B (HBV)
Abstract:
(EN) Disclosed herein are compounds, compositions, and methods for decreasing HBV mRNA, DNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate HBV-related diseases, disorders or conditions. Several embodiments are drawn to compounds comprising a modified double-stranded oligonucleotide consisting of 10 to 30 linked nucleosides per strand and having a nucleobase sequence comprising at least 8 contiguous nucleobases of any of the nucleobase sequences of SEQ ID NOs: 30-125.
(FR) La présente invention concerne des composés, des compositions, et des méthodes destinées à diminuer l'expression de l'ARNm, de l'ADN et des protéines du virus de l'hépatite B (HBV). De tels méthodes, composés, et compositions sont utiles dans le traitement, la prévention, ou l'amélioration de maladies, troubles ou états pathologiques associés au HBV. Plusieurs modes de réalisation concernent des composés comprenant un oligonucléotide double brin constitué de 10 à 30 nucléosides liés par brin et possédant une séquence comprenant au moins 8 nucléobases contiguës parmi les séquences de nucléobases de la SEQ ID NOs: 30-125.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)