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1. WO2013159092 - TUNABLE MULTIMODAL NANOPARTICLES AND METHODS OF USE THEREOF

Publication Number WO/2013/159092
Publication Date 24.10.2013
International Application No. PCT/US2013/037582
International Filing Date 22.04.2013
IPC
A61K 49/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
08characterised by the carrier
CPC
A61K 49/0002
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
0002General or multifunctional contrast agents, e.g. chelated agents
A61K 49/1857
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
18characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
1818particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
1821coated or functionalised microparticles or nanoparticles
1824coated or functionalised nanoparticles
1827having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
1851having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
1857the organic macromolecular compound being obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. PLGA
A61K 49/186
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
18characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
1818particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
1821coated or functionalised microparticles or nanoparticles
1824coated or functionalised nanoparticles
1827having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
1851having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
1857the organic macromolecular compound being obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. PLGA
186the organic macromolecular compound being polyethyleneglycol [PEG]
A61K 9/5031
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
5005Wall or coating material
5021Organic macromolecular compounds
5031obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
Applicants
  • BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA [US]/[US]
Inventors
  • LIU, Xin-Ming
  • KABANOV, Alexander V.
  • GENDELMAN, Howard E.
Agents
  • NETTER, Robert, C., Jr.
Priority Data
61/636,02920.04.2012US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TUNABLE MULTIMODAL NANOPARTICLES AND METHODS OF USE THEREOF
(FR) NANOPARTICULES MULTIMODALES ACCORDABLES ET PROCÉDÉS D'UTILISATION
Abstract
(EN)
Tunable nanoparticles and methods of use thereof are provided. Iri accordance with the instant invention, tunable nanoparticles comprising a metal nanoparticle core (e.g., a paramagnetic particle (e.g., USPIO) or a quantum dot) and a polymer linked to a metal binding moiety are provided. The polymer of the nanoparticle is bound to the metal nanoparticle core by the metal binding moiety and coats the metal nanoparticle core. In a particular embodiment, the metal binding moiety comprises bisphosphonate, pyrophosphate, or a derivative thereof. In a particular embodiment, the polymer is a hydrophilic polymer, an amphiphilic block copolymer or an ionic block copolymer.
(FR)
L'invention porte sur des nanoparticules accordables et des procédés d'utilisation de ces dernières. L'invention concerne des nanoparticules accordables renfermant un cœur de nanoparticule métallique (p.ex., une particule paramagnétique (p.ex., USPIO) ou un point quantique) et un polymère lié à un fragment de liaison du métal. Le polymère de la nanoparticule est lié au cœur de nanoparticule métallique par le fragment de liaison du métal et enrobe ledit cœur de nanoparticule métallique. Dans un mode de réalisation particulier, le fragment de liaison du métal comprend du bisphosphonate, du pyrophosphate, ou un dérivé de ces derniers. Dans un mode de réalisation particulier, le polymère est un polymère hydrophile, un copolymère séquencé amphiphile ou un copolymère séquencé ionique.
Also published as
Latest bibliographic data on file with the International Bureau