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1. (WO2013159091) MIRNA MODULATORS OF THERMOGENESIS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/159091 International Application No.: PCT/US2013/037579
Publication Date: 24.10.2013 International Filing Date: 22.04.2013
IPC:
C12N 15/113 (2010.01) ,A61K 48/00 (2006.01) ,C07H 21/02 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
02
with ribosyl as saccharide radical
Applicants:
APTAMIR THERAPEUTICS, INC. [US/US]; 484 Terracina Way Naples, Florida 34119, US
Inventors:
THIBONNIER, Marc; US
Agent:
WILSON, Mark, B.; FULBRIGHT & JAWORSKI LLP 98 San Jacinto Blvd., Suite 1100 Austin, TX 78701, US
Priority Data:
61/636,05920.04.2012US
61/681,75010.08.2012US
61/782,83814.03.2013US
Title (EN) MIRNA MODULATORS OF THERMOGENESIS
(FR) MODULATEURS DE MICROARN DE LA THERMOGENÈSE
Abstract:
(EN) Provided are novel methods and compositions for the modulation of thermogenesis. Such methods are particularly advantageous in that they allow for the reduction of body fat in a subject without the subject having to adjust their caloric intake through dieting, modify their physical activity or undergo bariatric surgery. Accordingly, the methods of the invention are particularly useful for treating or preventing obesity. Also provided are methods of screening for novel agents that modulate the activity of thermogenic regulators.
(FR) La présente invention concerne de nouveaux procédés et des nouvelles compositions, permettant la modulation de la thermogenèse. Lesdits procédés sont particulièrement avantageux en ce qu'ils permettent la réduction de la graisse corporelle chez un sujet sans que ledit sujet ait besoin d'adapter son apport calorique par un régime, de modifier son activité physique ni de subir une chirurgie bariatrique. En conséquence, les procédés selon l'invention sont particulièrement utiles dans le traitement ou la prévention de l'obésité. L'invention a également trait à des procédés de criblage de nouveaux agents qui modulent l'activité des régulateurs thermogéniques.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)