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1. (WO2013159035) HIGHLY SENSITIVE SURVEILLANCE USING DETECTION OF CELL FREE DNA
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/159035 International Application No.: PCT/US2013/037439
Publication Date: 24.10.2013 International Filing Date: 19.04.2013
IPC:
C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
MEDICAL COLLEGE OF WISCONSIN, INC. [US/US]; Office Of Technology Development 8701 Watertown Plank Road Milwaukee, WI 53226, US
Inventors:
MITCHELL, Aoy, Tomita; US
MITCHELL, Michael; US
Agent:
VATLAND, Janice, A.; Wolf, Greenfield & Sacks, P.C. 600 Atlantic Avenue Boston, MA 02210-2206, US
Priority Data:
61/635,72319.04.2012US
61/700,87313.09.2012US
61/798,42115.03.2013US
Title (EN) HIGHLY SENSITIVE SURVEILLANCE USING DETECTION OF CELL FREE DNA
(FR) SURVEILLANCE HAUTEMENT SENSIBLE UTILISANT UNE DÉTECTION D'ADN ACELLULAIRE
Abstract:
(EN) Provided herein are methods and computer-readable storage media related to cell-free DNA and uses thereof to determine risk of a condition in a subject. In one embodiment, the method comprises analyzing nucleic acids from cell-free DNA extracted from a biological sample obtained from the subject to identify a plurality of loci, the nucleic acids comprising first nucleic acids of the subject and second nucleic acids not native to the subject; determining an allele of each of the plurality of loci; selecting at least one informative locus from the plurality of loci based on the determining of the allele; calculating an estimated allele frequency of a first allele at the at least one informative locus using a statistical distribution; determining an amount of cell-free DNA not native to the subject in the cell-free DNA based on the estimated allele frequency; and determining a risk in the subject.
(FR) L'invention concerne des procédés et des supports de données pouvant être lus informatiquement concernant un ADN acellulaire et les utilisations de ceux-ci pour déterminer le risque d'un état, tel qu'un rejet de transplantation ou d'un cancer, chez un sujet.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)