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1. (WO2013159005) A METHOD OF IMPROVING THE ACTIVITY OF CELLULASE ENZYME MIXTURES IN THE SACCHARIFICATION OF (LIGNO)CELLULOSIC MATERIAL
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/159005 International Application No.: PCT/US2013/037390
Publication Date: 24.10.2013 International Filing Date: 19.04.2013
IPC:
C12N 1/15 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
14
Fungi; Culture media therefor
15
modified by introduction of foreign genetic material
Applicants: EMALFARB, Mark[US/US]; US
SINITSYN, Arkady[RU/RU]; RU
JUNDZIL, Richard[US/US]; US
WERY, Jan[NL/NL]; NL
VISSER, Jacob[NL/NL]; NL
JOOSTEN, Rob[NL/NL]; NL
KOETSIER, Martijn[NL/NL]; NL
DYADIC INTERNATIONAL (USA) LTD.[US/US]; 140 Intracoastal Pointe Drive Jupiter, Florida 33477, US
Inventors: EMALFARB, Mark; US
SINITSYN, Arkady; RU
JUNDZIL, Richard; US
WERY, Jan; NL
VISSER, Jacob; NL
JOOSTEN, Rob; NL
KOETSIER, Martijn; NL
Agent: LUCKOW, Verne A.; Roetzel & Andress 350 East Las Olas Boulevard Suite 1150 Fort Lauderdale, Florida 33301, US
Priority Data:
61/635,85019.04.2012US
Title (EN) A METHOD OF IMPROVING THE ACTIVITY OF CELLULASE ENZYME MIXTURES IN THE SACCHARIFICATION OF (LIGNO)CELLULOSIC MATERIAL
(FR) PROCÉDÉ D'AMÉLIORATION DE L'ACTIVITÉ DE MÉLANGES D'ENZYMES CELLULASES DANS LA SACCHARIFICATION DE MATÉRIAU (LIGNO)CELLULOSIQUE
Abstract:
(EN) The present invention relates to modified filamentous fungal organisms having improved activity profiles with respect to the conversion of complex carbohydrates into simple sugars from cellulosic materials, including fungal organisms belonging to a genus selected from the group consisting of: Chrysosporium, Thielavia, Talaromyces, Thermomyces, Thermoascus, Neurospora, Aureobasidium, Filibasidium, Piromyces, Corynascus, Cryplococcus, Acremonium, Tolypocladium, Scytalidium, Schizophyllum, Sporotrichum, Penicillium, Gibberella, Myceliophthora, Mucor, Aspergillus, Fusarium, Humicola, Trichoderma, and Talaromyces, plus anamorphs and teleomorphs thereof. Filamentous fungal organisms having improved activity profiles are obtained by modifying genes encoding enzymes involved in the production of cellobionolactone, cellobionic acid, gluconolactone, gluconic acid, and related products, by a variety of mutagenic methods, resulting in nucleotide substitutions, insertions, and deletions, increasing the level of saccharification in enzyme mixtures obtained from the modified organisms.
(FR) La présente invention concerne des organismes fongiques filamenteux modifiés ayant des profils d'activité améliorés en ce qui concerne la conversion de glucides complexes en sucres simples à partir de matériaux cellulosiques, comprenant des organismes fongiques appartenant à un genre choisi dans le groupe constitué de : Chrysosporium, Thielavia, Talaromyces, Thermomyces, Thermoascus, Neurospora, Aureobasidium, Filibasidium, Piromyces, Corynascus, Cryplococcus, Acremonium, Tolypocladium, Scytalidium, Schizophyllum, Sporotrichum, Penicillium, Gibberella, Myceliophtora, Mucor, Aspergillus, Fusarium, Humicola, Trichoderma, et Talaromyces, ainsi que des anamorphes et des téléomorphes de ceux-ci. Des organismes fongiques filamenteux ayant des profils d'activité améliorés sont obtenus par modification de gènes codant pour des enzymes impliquées dans la production de cellobionolactone, acide cellobionique, gluconolactone, acide gluconique, et des produits associés, par différents procédés de mutagenèse, conduisant à des substitutions, insertions, et délétions de nucléotide, augmentant le taux de saccharification dans des mélanges d'enzymes obtenus à partir des organismes modifiés.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)