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1. (WO2013158936) MONITORING IMMUNOGLOBULIN HEAVY CHAIN EVOLUTION IN B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

Pub. No.:    WO/2013/158936    International Application No.:    PCT/US2013/037258
Publication Date: Fri Oct 25 01:59:59 CEST 2013 International Filing Date: Fri Apr 19 01:59:59 CEST 2013
IPC: C12Q 1/68
C07H 21/04
Applicants: SEQUENTA, INC
PEPIN, Francois
CARLTON, Victoria
KLINGER, Mark
FAHAM, Malek
Inventors: PEPIN, Francois
CARLTON, Victoria
KLINGER, Mark
FAHAM, Malek
Title: MONITORING IMMUNOGLOBULIN HEAVY CHAIN EVOLUTION IN B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
Abstract:
The invention is directed to methods of monitoring B-cell lymphoid proliferative disorders, such as B-cell acute lymphoblastic leukemias, by measuring the presence, absence and/or levels of correlating, or index, clonotypes and related clonotypes that have evolved therefrom, for example, as part of the disease condition. In one aspect, such methods are implemented by generating sequencing-based clonotype profiles and determining frequencies of correlating, or index, clonotypes present, including new clonotypes that have evolved therefrom, particularly, in the case of B-cell ALL, by VH substitution. The invention also includes use of such monitoring information to modify treatment status of a patient.