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1. (WO2013158618) MAGNESIUM COMPOSITIONS FOR MODULATING THE PHARMACOKINETICS AND PHARMACODYNAMICS OF INSULIN AND INSULIN ANALOGS, AND INJECTION SITE PAIN
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/158618 International Application No.: PCT/US2013/036742
Publication Date: 24.10.2013 International Filing Date: 16.04.2013
Chapter 2 Demand Filed: 17.02.2014
IPC:
A61K 9/00 (2006.01) ,A61K 38/28 (2006.01) ,A61K 47/02 (2006.01) ,A61K 47/12 (2006.01) ,A61K 47/18 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
22
Hormones
28
Insulins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
02
Inorganic compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
12
Carboxylic acids; Salts or anhydrides thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
16
containing nitrogen
18
Amines; Quaternary ammonium compounds
Applicants:
BIODEL INC. [US/US]; 100 Saw Mill Road Danbury, CT 06810, US
Inventors:
POHL, Roderike; US
HAUSER, Robert; US
LI, Ming; US
WILSON, Bryan, R.; US
Agent:
PABST, Patrea, L.; Pabst Patent Group LLP 1545 Peachtree Street, N.E. Suite 320 Atlanta, GA 30309, US
Priority Data:
13/826,80614.03.2013US
61/624,84416.04.2012US
61/704,06621.09.2012US
Title (EN) MAGNESIUM COMPOSITIONS FOR MODULATING THE PHARMACOKINETICS AND PHARMACODYNAMICS OF INSULIN AND INSULIN ANALOGS, AND INJECTION SITE PAIN
(FR) COMPOSITIONS DE MAGNÉSIUM POUR MODULER LA PHARMACOCINÉTIQUE ET LA PHARMACODYNAMIQUE DE L'INSULINE ET D'ANALOGUES DE L'INSULINE, ET LA DOULEUR AU SITE D'INJECTION
Abstract:
(EN) Compositions and methods for modulating injection site pain associated with rapid acting injectable insulin formulations have been developed for subcutaneous injection. The formulations contain insulin in combination with a zinc chelator such as ethylenediaminetetraacetic acid ("EDTA"), a dissolution/stabilization agent such as citric acid, a magnesium salt, and, optionally, additional excipients. New presentations include rapid acting concentrated insulin formulations and a way to enhance the absorption of commercially available rapid acting analog formulations by mixing them with a vial containing dry powder excipients that accelerate their absorption. Devices for mixing excipient and insulin together at the time of administration, while minimizing residence time of the mixture, are also described.
(FR) L'invention porte sur des compositions et sur des procédés qui permettent de moduler la douleur ressentie au niveau d'un site d'injection et associée à des formulations d'insuline injectables à action rapide pour injection sous-cutanée. Les formulations contiennent de l'insuline en association avec un chélateur du zinc, tel que l'acide éthylènediaminetétraacétique (« EDTA »), un agent de dissolution/stabilisation, tel que l'acide citrique, un sel de magnésium et, éventuellement, des excipients supplémentaires. Les nouvelles présentations comprennent des formulations d'insuline concentrées à action rapide et une manière d'accroître l'absorption de formulations analogues à action rapide, disponibles dans le commerce, en mélangeant celles-ci avec un flacon contenant des excipients en poudre sèche qui accélèrent leur absorption. L'invention porte également sur des dispositifs pour le mélange d'excipient et d'insuline l'un avec l'autre au moment de l'administration, tout en réduisant à un minimum le temps de séjour du mélange.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)