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1. (WO2013158389) ELISA ASSAY KIT, ELISA FOR DETERMINING DESMOSINE LEVELS FROM URINE SAMPLES AND DIAGNOSTIC URINE ASSAYS FOR ANEURYSMS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/158389 International Application No.: PCT/US2013/035553
Publication Date: 24.10.2013 International Filing Date: 08.04.2013
IPC:
G01N 33/53 (2006.01) ,G01N 33/567 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
566
using specific carrier or receptor proteins as ligand binding reagent
567
utilising isolate of tissue or organ as binding agent
Applicants: ADI INCORPORATED[US/US]; 10900 73rd Avenue North, Suite 150 Maple Grove, MN 55369, US
Inventors: STARCHER, Barry C.; US
DURWARD, Marina A.; US
LYNCH, Laurie; US
OGLE, Matthew F.; US
Agent: DARDI, Peter S.; DARDI & HERBERT, PLLC Moore Lake Plaza, Suite 205 1250 East Moore Lake Drive Fridley, MN 55432, US
Priority Data:
13/448,73417.04.2012US
Title (EN) ELISA ASSAY KIT, ELISA FOR DETERMINING DESMOSINE LEVELS FROM URINE SAMPLES AND DIAGNOSTIC URINE ASSAYS FOR ANEURYSMS
(FR) TROUSSE POUR TEST ELISA, ELISA POUR LA DÉTERMINATION DES NIVEAUX DE DESMOSINE DANS DES ÉCHANTILLONS D'URINE, ET ANALYSES D'URINE POUR LE DIAGNOSTIC D'ANÉVRISMES
Abstract:
(EN) Improved ELISA assay formats are described that provide for effective measurement of desmosine, an elastin degradation product, in urine samples. The urine samples can be effectively introduced into the assay with little or no sample preparation. The competitive ELISA assay based on high titer polyclonal antibodies is suitable for commercial application. Desirable antibodies can be generated using desmosine bound to a protein or the like using a protein crosslinking agent. The desmosine assay are found to be useful for the diagnosis of aortic aneurysms in which desmosine levels of patients with aortic aneurysms have been found to be significantly elevated relative to a control group.
(FR) L'invention concerne des formats améliorés du test ELISA qui permettent une mesure efficace de la desmosine, un produit de dégradation de l'élastine, dans des échantillons d'urine. Les échantillons d'urine peuvent être efficacement introduits dans l'analyse avec peu ou aucune préparation d'échantillon. Le test ELISA compétitif sur la base d'anticorps polyclonaux à titre élevé est approprié pour une application commerciale. Des anticorps souhaitables peuvent être générés à l'aide de la desmosine liée à une protéine ou autres, à l'aide d'un agent de réticulation protéique. Les dosages de desmosine ont été découverts comme étant utiles pour le diagnostic d'anévrismes aortiques dans lesquels les niveaux de desmosine de patients atteints d'anévrismes aortiques se sont révélés être significativement élevés par rapport à un groupe témoin.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)