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1. (WO2013158061) RECOMBINANT MYCOBACTERIUM ENCODING A HEPARIN-BINDING HEMAGGLUTININ (HBHA) FUSION PROTEIN AND USES THEREOF

Pub. No.:    WO/2013/158061    International Application No.:    PCT/US2012/033757
Publication Date: Fri Oct 25 01:59:59 CEST 2013 International Filing Date: Tue Apr 17 01:59:59 CEST 2012
IPC: C12N 1/21
C12N 15/62
C07K 19/00
C12P 21/00
Applicants: AERAS GLOBAL TB VACCINE FOUNDATION
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
FULKERSON, John
BRENNAN, Michael
VELMURUGAN, Kamalakannan
LOCHT, Camille
Inventors: FULKERSON, John
BRENNAN, Michael
VELMURUGAN, Kamalakannan
LOCHT, Camille
Title: RECOMBINANT MYCOBACTERIUM ENCODING A HEPARIN-BINDING HEMAGGLUTININ (HBHA) FUSION PROTEIN AND USES THEREOF
Abstract:
Recombinant Mycobacteria (rMyc) which contain sequences encoding a heparin- binding hemagglutinin (HBHA) fusion protein are provided, as are methods of making and using the rMyc and the fusion protein. The fusion protein includes an amino terminal mycobacterial antigen Ag85B leader peptide and transcription of the fusion protein is driven by an Ag85B promoter sequence. The recombinant fusion protein is produced in abundance by the rMyc, is post-translationally methylated, and is highly antigenic.