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1. (WO2013158061) RECOMBINANT MYCOBACTERIUM ENCODING A HEPARIN-BINDING HEMAGGLUTININ (HBHA) FUSION PROTEIN AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/158061    International Application No.:    PCT/US2012/033757
Publication Date: 24.10.2013 International Filing Date: 16.04.2012
IPC:
C12N 1/21 (2006.01), C12N 15/62 (2006.01), C07K 19/00 (2006.01), C12P 21/00 (2006.01)
Applicants: AERAS GLOBAL TB VACCINE FOUNDATION [US/US]; 1405 Research Boulevard, 3rd Floor Rockville, MD 20850 (US) (For All Designated States Except US).
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) [FR/FR]; 101 rue de Tolbiac F-75654 Paris (FR) (For All Designated States Except US).
FULKERSON, John [US/US]; (US) (For US Only).
BRENNAN, Michael [US/US]; (US) (For US Only).
VELMURUGAN, Kamalakannan [IN/US]; (US) (For US Only).
LOCHT, Camille [BE/BE]; (BE) (For US Only)
Inventors: FULKERSON, John; (US).
BRENNAN, Michael; (US).
VELMURUGAN, Kamalakannan; (US).
LOCHT, Camille; (BE)
Agent: LEGAARD, Paul, K.; Pepper Hamilton LLP 400 Berwyn Park 899 Cassatt Park Berwyn, PA 19312 (US)
Priority Data:
Title (EN) RECOMBINANT MYCOBACTERIUM ENCODING A HEPARIN-BINDING HEMAGGLUTININ (HBHA) FUSION PROTEIN AND USES THEREOF
(FR) MYCOBACTÉRIE RECOMBINÉE CODANT POUR UNE PROTÉINE DE FUSION HÉMAGGLUTININE SE LIANT À L'HÉPARINE (HBHA) ET SES UTILISATIONS
Abstract: front page image
(EN)Recombinant Mycobacteria (rMyc) which contain sequences encoding a heparin- binding hemagglutinin (HBHA) fusion protein are provided, as are methods of making and using the rMyc and the fusion protein. The fusion protein includes an amino terminal mycobacterial antigen Ag85B leader peptide and transcription of the fusion protein is driven by an Ag85B promoter sequence. The recombinant fusion protein is produced in abundance by the rMyc, is post-translationally methylated, and is highly antigenic.
(FR)La présente invention concerne des mycobactéries recombinées (rMyc) qui contiennent des séquences codant pour une protéine de fusion hémagglutinine se liant à l'héparine (HBHA), ainsi que des méthodes de fabrication et d'utilisation des rMyc et de la protéine de fusion. La protéine de fusion comprend un peptide signal antigène mycobactérien N-terminal Ag85B et la transcription de la protéine de fusion est entraînée par une séquence promoteur du Ag85B. La protéine de fusion recombinée est produite en abondance par les rMyc, est méthylée lors d'une modification post-traductionnelle, et est fortement antigénique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)