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1. (WO2013157954) METHODS AND MEANS FOR THE PRODUCTION OF IG-LIKE MOLECULES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/157954    International Application No.:    PCT/NL2013/050294
Publication Date: 24.10.2013 International Filing Date: 19.04.2013
IPC:
C07K 16/12 (2006.01), C07K 16/26 (2006.01), C07K 16/36 (2006.01), C07K 16/46 (2006.01)
Applicants: MERUS B.V. [NL/NL]; Padualaan 8 (postvak 133) NL-3584 CH Utrecht (NL)
Inventors: DE KRUIF, Cornelis Adriaan; (NL).
HENDRIKS, Linda Johanna Aleida; (NL).
LOGTENBERG, Ton; (NL)
Agent: JANSEN, C.M.; Johan de Wittlaan 7 NL-2517 JR Den Haag (NL)
Priority Data:
61/635,935 20.04.2012 US
Title (EN) METHODS AND MEANS FOR THE PRODUCTION OF IG-LIKE MOLECULES
(FR) PROCÉDÉS ET MOYENS DE PRODUCTION DE MOLÉCULES DE TYPE IG
Abstract: front page image
(EN)The invention provides means and methods for producing one or more Ig-like molecules in a single host cell. Novel CH3 mutations enabling the production of monospecific and/or bispecific Ig-like molecules of interest are also provided.
(FR)L'invention concerne des moyens et des procédés de production d'une ou de plusieurs molécules de type Ig dans une cellule hôte unique. De nouvelles mutations CH3, permettant la production de molécules d'intérêt de type Ig monospécifique et/ou bispécifique, sont également décrites.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)