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Pub. No.:    WO/2013/157583    International Application No.:    PCT/JP2013/061413
Publication Date: 24.10.2013 International Filing Date: 17.04.2013
C07D 477/00 (2006.01), A61K 31/407 (2006.01), A61P 31/04 (2006.01), A61P 43/00 (2006.01), C07D 487/04 (2006.01)
Applicants: DAINIPPON SUMITOMO PHARMA CO., LTD. [JP/JP]; 6-8, Dosho-machi 2-chome, Chuo-ku, Osaka-shi, Osaka 5418524 (JP)
Inventors: HASHIZUKA, Takahiko; (JP).
TSUKIMURA, Takashi; (JP).
SHIMOMAE, Katsunari; (JP)
Agent: TAKASHIMA, Hajime; Meiji Yasuda Seimei Osaka Midosuji Bldg., 1-1, Fushimimachi 4-chome, Chuo-ku, Osaka-shi, Osaka 5410044 (JP)
Priority Data:
2012-095012 18.04.2012 JP
(JA) 新規カルバペネム化合物
Abstract: front page image
(EN)The purpose of the invention is to provide a compound having excellent antimicrobial activity and oral absorbability, and comprising a crystal form having storage stability that permits practical use as a pharmaceutical ingredient. The invention provides a carbapenem compound represented by formula (I) (in the formula, R1 indicates a hydrogen atom or C1-6 alkyl group, and R2 indicates -NH(C=O)OMe or -O(C=O)NHMe) and crystals thereof.
(FR)Le but de la présente invention est de produire un composé présentant d'excellentes propriétés d'activité antimicrobienne et d'absorbabilité orale, et comprenant une forme cristalline ayant une stabilité de stockage qui permet une utilisation pratique comme ingrédient pharmaceutique. L'invention concerne ainsi un composé de carbapénème représenté par la formule (I) (dans la formule, R1 représente un atome d'hydrogène ou un groupe alkyle en C1 à C6, et R2 représente -NH(C=O)OMe ou -O(C=O)NHMe) et ses cristaux.
(JA) 本発明の目的は、優れた抗菌活性および経口吸収性を有し、かつ医薬原体として実用化が可能な保存安定性を有する結晶形からなる化合物の提供することである。 本発明によれば、式(I):(式中、Rは水素原子またはC1-6アルキル基を示し、Rは、-NH(C=O)OMeまたは-O(C=O)NHMeを示す。)で表されるカルバペネム化合物、及びその結晶が提供される。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)