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1. WO2013157410 - FZD10-BINDING PEPTIDE

Publication Number WO/2013/157410
Publication Date 24.10.2013
International Application No. PCT/JP2013/060465
International Filing Date 05.04.2013
IPC
C07K 7/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 49/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 7/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
08having 12 to 20 amino acids
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 14/4748
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4748Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
C07K 7/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
Applicants
  • HOYA株式会社 HOYA CORPORATION [JP]/[JP]
  • 公益財団法人がん研究会 JAPANESE FOUNDATION FOR CANCER RESEARCH [JP]/[JP]
Inventors
  • 飯森 祐介 IIMORI, Yusuke
  • 山形 瑞恵 YAMAGATA, Mizue
  • 塩野 智隆 SHIONO, Toshitaka
  • 芝 清隆 SHIBA, Kiyotaka
Agents
  • 特許業務法人アルガ特許事務所 THE PATENT CORPORATE BODY ARUGA PATENT OFFICE
Priority Data
2012-09398217.04.2012JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) FZD10-BINDING PEPTIDE
(FR) PEPTIDE DE LIAISON DE FZD10
(JA) FZD10結合性ペプチド
Abstract
(EN)
Provided are a substance that binds to FZD10 specifically and at high affinity and a drug containing the same. A peptide of 11-50 amino acids having at least an amino acid sequence represented by formula (1). (In the formula, X1 indicates Leu or Met; X2 indicates Pro, Val, Ile, Met, or Leu; X3 indicates Ser, Ala, Thr, Gly, Asn, Asp, Glu, Arg, or Lys; X4 indicates Leu, Met, Phe, or Trp; X5 indicates His, Tyr, Phe, Lys, Arg, Ala, Leu, or Met; X6 indicates Met, Leu, Ile, Val, Ala, Phe, Tyr, Trp, or Cys; and X7 indicates Tyr or Phe.)
(FR)
L'invention concerne une substance qui se lie de manière spécifique et avec une haute affinité à FZD10, et un médicament la contenant. Un peptide de 11-50 acides aminés présentant au moins une séquence d'acides aminés représentée par une formule (1) est décrit. (Dans la formule, X1 signifie Leu ou Met ; X2 signifie Pro, Val, Ile, Met, ou Leu ; X3 signifie Ser, Ala, Thr, Gly, Asn, Asp, Glu, Arg, ou Lys ; X4 signifie Leu, Met, Phe, ou Trp ; X5 signifie His, Tyr, Phe, Lys, Arg, Ala, Leu, ou Met ; X6 signifie Met, Leu, Ile, Val, Ala, Phe, Tyr, Trp, ou Cys ; et X7 signifie Tyr ou Phe.)
(JA)
 FZD10に特異的かつ高親和性で結合する物質及びそれを含む医薬の提供。 少なくとも下記式(1)で表されるアミノ酸配列を有するアミノ酸数11~50の ペプチド。 (式中、XはLue又はMetを示し、 XはPro、Val、Ile、Met又はLeuを示し、 XはSer、Ala、Thr、Gly、Asn、Asp、Glu、Arg又はLysを示し、 XはLeu、Met、Phe又はTrpを示し、 XはHis、Tyr、Phe、Lys、Arg、Ala、Leu又はMetを示し、 XはMet、Leu、Ile、Val、Ala、Phe、Tyr、Trp又はCysを示し、 XはTyr又はPheを示す。)
Also published as
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