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1. (WO2013157022) SUBSTITUTED HETERO-BICYCLIC COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/157022    International Application No.:    PCT/IN2013/000259
Publication Date: 24.10.2013 International Filing Date: 18.04.2013
IPC:
C07D 413/14 (2006.01), A61K 31/519 (2006.01), C07D 403/14 (2006.01), A61P 19/02 (2006.01)
Applicants: ADVINUS THERAPEUTICS LIMITED [IN/IN]; 21 & 22 Peenya Industrial Area, Phase II Bangalore 560 058 (IN)
Inventors: THAKKAR, Mahesh; (IN).
KOUL, Summon; (IN).
BHUNIYA, Debnath; (IN).
MOOKHTIAR, Kasim; (IN).
KURHADE, Santosh; (IN).
MUNOT, Yogesh; (IN)
Agent: LAKSHMIKUMARAN, Malathi; B-6/10 Safdarjung Enclave New Delhi 110029 (IN)
Priority Data:
1573/CHE/2012 20.04.2012 IN
Title (EN) SUBSTITUTED HETERO-BICYCLIC COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF
(FR) COMPOSÉS HÉTÉRO-BICYCLIQUES SUBSTITUÉS, COMPOSITIONS ET LEURS APPLICATIONS MÉDICINALES
Abstract: front page image
(EN)The present disclosure provides hetero-biclyclic compounds of formula (I), their tautomers, polymorphs, stereoisomers, prodrugs, solvates, hydrates, N-oxides, co-crystals, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by Bruton's tyrosine kinase (Btk) activity, The disclosure also relates to the process of preparation of compounds of Formula (I). These compounds are useful in the treatment, prevention, prophylaxis, management, or adjunct treatment of all medical conditions related to inhibition of Bruton's tyrosine kinase (Btk), such as inflammatory and/or autoimmune disorder, cell proliferation, rheumatoid arthritis, psoriasis, psoriatic arthritis, transplant rejection, graft-versus-host disease, multiple sclerosis, inflammatory bowel disease, allergic diseases, asthma, type 1 diabetes, myasthenia gravis, hematopoetic disfunction, B-cell malignancies, systemic lupus, erythematosus or other disorders.
(FR)La présente invention concerne des composés hétéro-bicycliques de formule (I), leurs tautomères, des polymorphes, des stéréoisomères, des promédicaments, des solvates, des hydrates, des N-oxydes, des co-cristaux, des sels pharmaceutiquement acceptables, des compositions pharmaceutiques les contenant, et des méthodes de traitement de pathologies et de maladies médiées par l'activité de la tyrosine kinase de Bruton (Btk). L'invention a également trait au procédé de préparation des composés de formule (I). Lesdits composés sont utiles dans le traitement, la prévention, la prophylaxie, la gestion ou le traitement complémentaire de tous les états pathologiques liés à l'inhibition de la tyrosine kinase de Bruton (Btk), telles que le trouble inflammatoire et/ou auto-immun, la prolifération cellulaire, la polyarthrite rhumatoïde, le psoriasis, la polyarthrite psoriasique, le rejet de greffe, la maladie du greffon contre l'hôte, la sclérose en plaques, la maladie inflammatoire chronique de l'intestin, les maladies allergiques, l'asthme, le diabète de type 1, la myasthénie, les troubles hématopoïétiques, les malignités à cellules B, le lupus érythémateux disséminé ou d'autres troubles.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)