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1. (WO2013156488) OPTIMISED SUBCUTANEOUS THERAPEUTIC AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/156488 International Application No.: PCT/EP2013/057928
Publication Date: 24.10.2013 International Filing Date: 16.04.2013
IPC:
A61K 47/48 (2006.01) ,A61P 7/04 (2006.01) ,A61P 31/00 (2006.01)
Applicants: CANTAB BIOPHARMACEUTICALS PATENTS LIMITED[MT/MT]; Palazzo Pietro Stiges 103 Strait Street Valetta VLT1436, MT
Inventors: HENRY, William; GB
WOLF-GARRAWAY, Richard; GB
MAYO, John Charles; GB
EARL, Michael James; GB
Agent: BASSIL, Nicholas; Kilburn & Strode LLP 20 Red Lion Street London WC1R 4PJ, GB
Priority Data:
1206628.816.04.2012GB
1213712.101.08.2012GB
1214985.222.08.2012GB
Title (EN) OPTIMISED SUBCUTANEOUS THERAPEUTIC AGENTS
(FR) AGENTS THÉRAPEUTIQUES SOUS-CUTANÉS OPTIMISÉS
Abstract:
(EN) Methods and dosage formulations are provided for subcutaneous administration in which therapeutic agents are modified to increase the hydrophilicity and molecular dimensions in relation to the native state of the therapeutic agent, in which the Cmax:Caverage ratio is lower than the Cmax:Caverage ratio of the agent when delivered intravenously.
(FR) L'invention concerne des procédés et des formulations posologiques pour administration sous-cutanée dans lesquels des agents thérapeutiques sont modifiés pour augmenter l'hydrophilie et les dimensions moléculaires par rapport à l'état natif de l'agent thérapeutique, le rapport Cmax/Cmoyen étant inférieur au rapport Cmax/Cmoyen de l'agent lorsqu'il est délivré par voie intraveineuse.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)