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1. WO2013156225 - OPTIMIZING UNGUAL TREATMENT BY QUANTITATIVE AUTORADIOGRAPHY

Publication Number WO/2013/156225
Publication Date 24.10.2013
International Application No. PCT/EP2013/055451
International Filing Date 15.03.2013
IPC
A61K 51/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
12characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
A61K 51/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier
04Organic compounds
A61K 31/137 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
135having aromatic rings, e.g. methadone
137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
A61P 31/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
10Antimycotics
CPC
A61K 31/137
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines
135having aromatic rings ; , e.g. ketamine, nortriptyline
137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine ; or methadone
A61K 51/0406
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier ; , i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
04Organic compounds
0404Lipids, e.g. triglycerides; Polycationic carriers
0406Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
A61K 51/121
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
12characterised by a special physical form, e.g. emulsion, microcapsules, liposomes ; , characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
121Solutions, i.e. homogeneous liquid formulation
A61K 9/0014
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0014Skin, i.e. galenical aspects of topical compositions
A61M 2037/0007
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
37Other apparatus for introducing media into the body
0007having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
A61M 37/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
37Other apparatus for introducing media into the body
Applicants
  • GALDERMA RESEARCH & DEVELOPMENT [FR]/[FR]
Inventors
  • OSMAN-PONCHET, Hanan
  • BOUCLIER, Martine
Agents
  • MARTIN-CHARBONNEAU, Virginie
Priority Data
61/63624020.04.2012US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) OPTIMIZING UNGUAL TREATMENT BY QUANTITATIVE AUTORADIOGRAPHY
(FR) OPTIMISATION D'UN TRAITEMENT DES ONGLES PAR AUTORADIOGRAPHIE QUANTITATIVE
Abstract
(EN)
A method for optimizing ungual treatment includes (a) providing a nail having at least two spaced apart holes formed from a surface thereof and extending into the nail, and (b) topically applying a radiolabeled pharmaceutical composition to the nail. At least a portion of the composition is received in the at least two holes. The method also includes (c) sectioning a portion of the nail proximate the at least two holes into a plurality of sections, (d)determining, for each of the plurality of sections, a concentration of radio activity in the section as a function of position with respect to the at least two holes, and (e) optimizing a spacing between the at least two holes based at least partially on the determinations in step (d). A method of ungual treatment using the optimized spacing is also described.
(FR)
L'invention concerne un procédé d'optimisation d'un traitement des ongles, qui consiste à: a) utiliser une ongle à la surface de laquelle sont percés au moins deux trous espacés s'étendant à l'intérieur de l'ongle; et b) appliquer sur l'ongle une composition pharmaceutique topique radiomarquée. Au moins une partie de la composition pénètre dans lesdits au moins deux trous. Le procédé consiste également à: c) segmenter en plusieurs sections une partie de l'ongle, à proximité desdits au moins deux trous; d) déterminer, dans chaque section, une concentration de radio-activité en fonction d'une position relative auxdits au moins deux trous; et e) optimiser un espacement entre lesdits au moins deux trous en se fondant au moins partiellement sur les déterminations de l'étape d). L'invention concerne également un procédé de traitement des ongles utilisant l'espacement optimisé.
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