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1. (WO2013155460) TUBERCULOSIS BIOMARKERS AND USES THEREOF

Pub. No.:    WO/2013/155460    International Application No.:    PCT/US2013/036447
Publication Date: Fri Oct 18 01:59:59 CEST 2013 International Filing Date: Sat Apr 13 01:59:59 CEST 2013
IPC: C12Q 1/68
Applicants: SOMALOGIC, INC.
Inventors: OCHSNER, Urs
STERLING, David G.
JANJIC, Nebojsa
Title: TUBERCULOSIS BIOMARKERS AND USES THEREOF
Abstract:
The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection, treatment and diagnosis of tuberculosis (TB). In one aspect, the present application includes the identification of biomarkers that can be used alone or in various combinations for the detection of TB, including those set forth in Tables 1, 2, 4, 5, and 8 to 12. In another aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose or prognose TB or follow treatment response. In another aspect, methods are provided for diagnosing TB in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Tables 1, 2, 4, 5, and 8 to 12, wherein the individual is classified as having TB, or the likelihood of the individual having TB is determined, based on the at least one biomarker value.