WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2013155441) FILOVIRUS CONSENSUS ANTIGENS, NUCLEIC ACID CONSTRUCTS AND VACCINES MADE THEREFROM, AND METHODS OF USING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/155441    International Application No.:    PCT/US2013/036413
Publication Date: 17.10.2013 International Filing Date: 12.04.2013
IPC:
A61K 39/12 (2006.01)
Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US/US]; 3160 Chestnut Street Suite 200 Philadelphia, Pennsylvania 19104 (US) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
WEINER, David B [US/US]; (US) (US only).
SHEDLOCK, Devon [US/US]; (US) (US only)
Inventors: WEINER, David B; (US).
SHEDLOCK, Devon; (US)
Agent: DELUCA, Mark; Pepper Hamilton LLP 899 Cassatt Road Berwyn, Pennsylvania 19312 (US)
Priority Data:
61/623,428 12.04.2012 US
Title (EN) FILOVIRUS CONSENSUS ANTIGENS, NUCLEIC ACID CONSTRUCTS AND VACCINES MADE THEREFROM, AND METHODS OF USING SAME
(FR) ANTIGÈNES CONSENSUS DE FILOVIRUS, CONSTRUCTIONS D'ACIDES NUCLÉIQUES ET VACCINS À BASE DE CEUX-CI, ET LEURS MÉTHODES D'UTILISATION
Abstract: front page image
(EN)Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus filovirus immunogen including a consensus Marburgvirus filovirus glycoprotein MARV GP immunogen, a consensus Ebolavirus Sudan filovirus glycoprotein SEBOV GP immunogen and a consensus Ebolavirus Zaire glycoprotein ZEBOV GP immunogen are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Immunomodulatory methods and methods of inducing an immune response against filovirus, particularly Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire are disclosed. Method of preventing filovirus infection, particularly infection by Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire and methods of treating individuals infected with filovirus infection, particularly infection by Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire are disclosed. Consensus filovirus proteins are disclosed.
(FR)La présente invention concerne des molécules d'acides nucléiques et des compositions contenant une ou plusieurs séquences d'acides nucléiques codant pour un immunogène consensus de filovirus comprenant un immunogène consensus MARV GP constitué d'une glycoprotéine de filovirus Marburg, un immunogène consensus SEBOV GP constitué d'une glycoprotéine de filovirus Ebola-Soudan et un immunogène consensus ZEBOV GP constitué d'une glycoprotéine du virus Ebola-Zaïre. Les séquences codantes comprennent éventuellement une séquence codante liée activable codant pour un peptide signal. L'invention concerne également des méthodes d'immunomodulation et des méthodes d'induction d'une réponse immunitaire contre les filovirus et, notamment, les virus Marburg, Ebola-Soudan et Ebola-Zaïre, ainsi que des méthodes de prévention d'une infection à filovirus et, notamment, d'une infection par les virus Marburg, Ebola-Soudan et Ebola-Zaïre, de même que des méthodes de traitement de personnes infectées par un filovirus et, notamment, par les virus Marburg, Ebola-Soudan et Ebola-Zaïre. L'invention concerne, par ailleurs, des protéines consensus de filovirus.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)