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1. WO2013155406 - CONTRAGESTION AND TREATING INFLAMMATION BY MODULATING SODIUM CHANNEL ACTIVITY IN THE EPITHELIUM

Publication Number WO/2013/155406
Publication Date 17.10.2013
International Application No. PCT/US2013/036358
International Filing Date 12.04.2013
IPC
A61K 31/4965 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4965Non-condensed pyrazines
A61K 38/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08Peptides having 5 to 11 amino acids
A61K 31/185 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C12N 15/113 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
A61P 15/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders; Contraceptives
04for inducing labour or abortion; Uterotonics
CPC
A61K 31/4965
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
4965Non-condensed pyrazines
A61K 31/558
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
557Eicosanoids, e.g. leukotrienes ; or prostaglandins
558having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
A61K 31/713
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
713Double-stranded nucleic acids or oligonucleotides
A61K 38/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08Peptides having 5 to 11 amino acids
A61P 15/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
04for inducing labour or abortion; Uterotonics
A61P 15/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
08for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
Applicants
  • THE CHINESE UNIVERSITY OF HONG KONG [CN]/[CN]
  • CHAN, Hsiao Chang [US]/[CN]
Inventors
  • CHAN, Hsiao Chang
  • RUAN, Ye Chun
  • JIANG, Xiachua
  • CHUNG, Yiu Wa
Agents
  • SCHIFF, J. Michael
Priority Data
61/623,52012.04.2012US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CONTRAGESTION AND TREATING INFLAMMATION BY MODULATING SODIUM CHANNEL ACTIVITY IN THE EPITHELIUM
(FR) CONTRAGESTION ET TRAITEMENT D'UNE INFLAMMATION PAR LA MODULATION DE L'ACTIVITÉ D'UN CANAL SODIQUE DANS L'ÉPITHÉLIUM
Abstract
(EN)
This invention is based on the discovery that activation of the endometrial epithelial sodium channel (ENaC) triggers PGE2 release and production, which is required for embryo implantation. This invention provides a system for developing pharmaceuticals that inhibit ENaC activity or decrease ENaC expression (for example, using small molecule drugs or siRNA). These pharmaceuticals can be used for birth control or contragestion, or to treat inflammatory conditions mediated by PGE2. This invention also provides a system for developing pharmaceuticals that activate endometrial ENaC or increasing its expression. These pharmaceuticals can be used for promoting embryo implantation.
(FR)
Cette invention repose sur la découverte que l'activation du canal sodique épithélial de l'endomètre (ENaC) déclenche la libération et la production de PGE2, celui-ci étant nécessaire pour l'implantation d'un embryon. Cette invention concerne un système pour le développement de produits pharmaceutiques qui inhibent l'activité d'ENaC ou qui diminuent l'expression d'ENaC (par exemple à l'aide de médicaments à petites molécules ou ARNsi). Ces produits pharmaceutiques peuvent être utilisés pour la contraception ou la contragestion, ou pour traiter des états inflammatoires à médiation par PGE2. Cette invention concerne également un système de développement de produits pharmaceutiques qui activent l'ENaC de l'endomètre ou qui augmentent son expression. Ces produits pharmaceutiques peuvent être utilisés pour la promotion de l'implantation d'un embryon.
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