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1. (WO2013155262) IMPROVING RESISTANCE TO SKELETAL MUSCLE FATIGUE

Pub. No.:    WO/2013/155262    International Application No.:    PCT/US2013/036114
Publication Date: Fri Oct 18 01:59:59 CEST 2013 International Filing Date: Fri Apr 12 01:59:59 CEST 2013
IPC: C12N 5/00
Applicants: CYTOKINETICS, INC
MALIK, Fady
JASPER, Jeffrey, R.
KENNEDY, Adam
HWEE, Darren
Inventors: MALIK, Fady
JASPER, Jeffrey, R.
KENNEDY, Adam
HWEE, Darren
Title: IMPROVING RESISTANCE TO SKELETAL MUSCLE FATIGUE
Abstract:
Provided are compounds, compositions and methods for improving resistance to skeletal muscle fatigue comprising administering an effective amount of a skeletal muscle troponin activator. Also provided are methods for improving resistance to fatigue, improving physical endurance, or reducing exercise intolerance in a subject suffering from a condition associated with muscle fatigue or weakness, such as heart failure.