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1. (WO2013155152) BIS-POLYMER LIPID-PEPTIDE CONJUGATES AND NANOPARTICLES THEREOF

Pub. No.:    WO/2013/155152    International Application No.:    PCT/US2013/035924
Publication Date: Fri Oct 18 01:59:59 CEST 2013 International Filing Date: Thu Apr 11 01:59:59 CEST 2013
IPC: A61K 38/00
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventors: XU, Ting
DONG, He
SHU, Jessica
DUBE, Nikhil
Title: BIS-POLYMER LIPID-PEPTIDE CONJUGATES AND NANOPARTICLES THEREOF
Abstract:
The present invention provides bis-polymer lipid-peptide conjugates containing a hydrophobic block and headgroup containing a helical peptide and two polymer blocks. The conjugates can self-assemble to form helix bundle subunits, which in turn assemble to provide micellar nanocarriers for drug cargos and other agents. Particles containing the conjugates and methods for forming the particles are also disclosed.