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1. (WO2013155152) BIS-POLYMER LIPID-PEPTIDE CONJUGATES AND NANOPARTICLES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/155152    International Application No.:    PCT/US2013/035924
Publication Date: 17.10.2013 International Filing Date: 10.04.2013
IPC:
A61K 38/00 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, 12 Floor Oakland, California 94607 (US)
Inventors: XU, Ting; (US).
DONG, He; (US).
SHU, Jessica; (US).
DUBE, Nikhil; (US)
Agent: TRIMBLE, Alexander R.; Kilpatrick Townsend & Stockton LLP Two Embarcadero Center, 8th Floor San Francisco, California 94111-3834 (US)
Priority Data:
61/622,330 10.04.2012 US
61/668,923 06.07.2012 US
Title (EN) BIS-POLYMER LIPID-PEPTIDE CONJUGATES AND NANOPARTICLES THEREOF
(FR) CONJUGUÉS LIPIDES-PEPTIDES BIPOLYMÉRIQUES ET LEURS NANOPARTICULES
Abstract: front page image
(EN)The present invention provides bis-polymer lipid-peptide conjugates containing a hydrophobic block and headgroup containing a helical peptide and two polymer blocks. The conjugates can self-assemble to form helix bundle subunits, which in turn assemble to provide micellar nanocarriers for drug cargos and other agents. Particles containing the conjugates and methods for forming the particles are also disclosed.
(FR)La présente invention concerne des conjugués lipides-peptides bipolymériques comprenant une séquence hydrophobe et un groupe de tête contenant un peptide hélicoïdal et deux séquences polymériques. Les conjugués peuvent s'auto-assembler pour former des sous-unités de faisceau d'hélices, qui à leur tour s'assemblent pour constituer des nanosupports micellaires destinés à des charges de médicaments et d'autres agents. La présente invention concerne également des particules contenant les conjugués et des procédés de formation des particules.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)