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1. (WO2013155119) DETECTION AND QUANTITATION OF SAMPLE CONTAMINATION IN IMMUNE REPERTOIRE ANALYSIS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/155119 International Application No.: PCT/US2013/035857
Publication Date: 17.10.2013 International Filing Date: 09.04.2013
IPC:
C12Q 1/68 (2006.01)
Applicants: ASBURY, Thomas[US/US]; US (US)
CARLTON, Victoria[US/US]; US (US)
FAHAM, Malek[US/US]; US (US)
MACEVICZ, Stephen[US/US]; US (US)
MOORHEAD, Martin[CH/US]; US (US)
WILLIS, Thomas[US/US]; US (US)
ZHENG, Jianbiao[US/US]; US (US)
SEQUENTA, INC.[US/US]; 400 East Jamie Court Suite 301 South San Francisco, CA 94080, US (AllExceptUS)
Inventors: ASBURY, Thomas; US
CARLTON, Victoria; US
FAHAM, Malek; US
MACEVICZ, Stephen; US
MOORHEAD, Martin; US
WILLIS, Thomas; US
ZHENG, Jianbiao; US
Agent: SEIDEL, Jeffrey, J.; Wilson Sonsini Goodrich & Rosati 650 Page Mill Road Palo Alto, CA 94304-1050, US
Priority Data:
13/834,79415.03.2013US
13/835,09315.03.2013US
61/624,00213.04.2012US
61/658,31711.06.2012US
61/738,27717.12.2012US
61/768,26922.02.2013US
Title (EN) DETECTION AND QUANTITATION OF SAMPLE CONTAMINATION IN IMMUNE REPERTOIRE ANALYSIS
(FR) DÉTECTION ET QUANTIFICATION DE LA CONTAMINATION D'ÉCHANTILLONS DANS UNE ANALYSE DE RÉPERTOIRE IMMUNOLOGIQUE
Abstract: front page image
(EN) The invention is directed to methods for detecting and quantifying nucleic acid contamination in a tissue sample of an individual containing T cells and/or B cells, which is used for generating a sequence-based clonotype profile. In one aspect, the invention is implemented by measuring the presence and/or level of an endogenous or exogenous nucleic acid tag by which nucleic acid from an intended individual can be distinguished from that of unintended individuals. Endogenous tags include genetic identity markers, such as short tandem repeats, rare clonotypes or the like, and exogenous tags include sequence tags employed to determine clonotype sequences from sequence reads.
(FR) L'invention concerne des procédés visant à détecter et quantifier la contamination des acides nucléiques dans un échantillon tissulaire d'un individu, qui contient des lymphocytes T et/ou des lymphocytes B, et qui est utilisé pour générer un profil de clonotype à base de séquences. Dans un aspect, l'invention consiste à mesurer la présence et/ou le niveau d'une étiquette d'acide nucléique endogène ou exogène permettant de distinguer entre acides nucléiques d'un individu concerné et acides nucléiques d'individus non concernés. Les étiquettes endogènes comprennent des marqueurs d'identités génétiques, tels que de courtes séquences de répétition tandem, et des clonotypes rares, ou analogues, les étiquettes exogènes comprenant des étiquettes de séquences utilisées pour déterminer les séquences de clonotypes à partir de résultats de séquençage.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)