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1. (WO2013154946) MICROFLUIDIC DEVICE, SYSTEM AND METHOD

Pub. No.:    WO/2013/154946    International Application No.:    PCT/US2013/035505
Publication Date: Fri Oct 18 01:59:59 CEST 2013 International Filing Date: Sat Apr 06 01:59:59 CEST 2013
IPC: G01N 33/53
Applicants: ALERE SAN DIEGO, INC.
Inventors: COFFEY, William Patrick
CRIVELLI, Paul Michael
DERFUS, Austin Matthew
DO, Tuan, Hoang
HAUPT, Remus Anders Brix
PARKER, Emily
RENEFF, Gregory
TOVAR, Armando Raul
Title: MICROFLUIDIC DEVICE, SYSTEM AND METHOD
Abstract:
A combination of capillary forces and gas pressure is used to control the movement of liquid samples within a microfluidic device. A liquid sample introduced to a proximal portion of a capillary channel of a microfluidic device moves by capillary action partway along the capillary channel. As the liquid sample moves, a pressure of a gas acting upon a distal gas-liquid interface of the liquid sample increases by an amount sufficient to stop further movement of the liquid sample. To initiate further movement of the liquid sample, a pump connected to a distal portion of the capillary channel decreases the pressure of the gas acting upon the distal gas-liquid interface of the liquid sample by an amount sufficient to permit the liquid sample to move by capillary action further along the capillary channel of the microfluidic device.