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1. (WO2013154870) HISTONE DEACETYLASES (HDACS) INHIBITORS

Pub. No.:    WO/2013/154870    International Application No.:    PCT/US2013/035004
Publication Date: Fri Oct 18 01:59:59 CEST 2013 International Filing Date: Wed Apr 03 01:59:59 CEST 2013
IPC: C07D 239/90
Applicants: ANNJI PHARMACEUTICAL CO., LTD.
HEALTHBANKS USA INC.
Inventors: CHERN, Ji-Wang
YU, Chao-Wu
CHANG, Pei-Teh
Title: HISTONE DEACETYLASES (HDACS) INHIBITORS
Abstract:
Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit are also disclosed. In an embodiment of the invention, the compound is (2E)-3-(2-ethyl-6-fluoro-3,4-dihydro-4-oxo-3-phenethylquina20lin-7-yl)-N-hydroxyacrylamide, or a salt thereof. In another embodiment of the invention, the compound is (2E)-3-(2-ethyl-7-f1uoro-3,4-dihydro-4-oxo-3-phenethylquinazolin-6-yl)-N-hydroxyacrylamide, (2E)-3-(7-chloro-2-ethyl-3,4-dihydro-4-oxo-3-phenethylquinazolin-6-yl)-N-hydroxyacrylamide, or a salt thereof. In another aspect the invention relates to a composition comprising a therapeutically effective amount of a compound as aforementioned, or a pharmaceutically acceptable salt, a solvate or hydrate, a prodrug, or a metabolite thereof, and a pharmaceutically acceptable carrier or vehicle.