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1. (WO2013154778) HOST TARGETED INHIBITORS OF DENGUE VIRUS AND OTHER VIRUSES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/154778    International Application No.:    PCT/US2013/032488
Publication Date: 17.10.2013 International Filing Date: 15.03.2013
IPC:
A61K 31/4745 (2006.01)
Applicants: DANA-FARBER CANCER INSTITUTE, INC. [US/US]; 450 Brookline Ave Boston, MA 02215 (US).
PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US/US]; 17 Quincy Street Cambridge, MA 02138 (US)
Inventors: GRAY, Nathanael; (US).
YANG, Priscilla; (US).
LIU, Qingsong; (US).
DE WISPELAERE, Melissanne; (FR)
Agent: BAKER, C., Hunter; Wolf, Greenfield & Sacks, P.C. 600 Atlantic Avenue Boston, MA 02210-2206 (US)
Priority Data:
61/622,828 11.04.2012 US
Title (EN) HOST TARGETED INHIBITORS OF DENGUE VIRUS AND OTHER VIRUSES
(FR) INHIBITEURS CIBLANT L'HÔTE DU VIRUS DE LA DENGUE ET D'AUTRES VIRUS
Abstract: front page image
(EN)Novel antiviral compounds of Formulae (I)-(III) are provided: (I) (II) (III) The inventive compounds, pharmaceutical compositions thereof, and kits including the inventive compounds are useful for the prevention and treatment of infectious diseases caused by viruses, for example, by Flaviviridae virus (e.g., Dengue virus (DENY)), Kunjin virus, Japanese encephalitis virus, vesicular stomatitis virus (VSV), herpes simplex virus 1 (HSV-1), human cytomegalovirus (HCMV), poliovirus, Junin virus, Ebola virus, Marburg virus (MARV), Lassa fever virus (LASV), Venezuelan equine encephalitis virus (VEEV), or Rift Valley Fever virus (RVFV).
(FR)La présente invention concerne des composés antiviraux inédits de formule (I) à(III) : (I) (II) (III) Les composés de l'invention, ainsi que des compositions pharmaceutiques et des nécessaires en contenant peuvent être utilisés en vue de la prévention et du traitement de maladies infectieuses provoquées par des virus, par exemple par des virus de la famille des Flaviviridae (comme le virus de la dengue (DENY)), le virus Kunjin, le virus de l'encéphalite japonaise, le virus de la stomatite vésiculaire (VSV), le virus de l'herpès de type 1 (HSV-1), le cytomégalovirus humain (HCMV), le virus de la poliomyélite, le virus Junin, le virus Ebola, le virus de Marburg (MARV), le virus de la fièvre de Lassa (LASV), le virus de l'encéphalite équine du Vénézuéla (VEEV) ou le virus de la fièvre de la vallée du Rift (RVFV).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)