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1. (WO2013154759) BENZOXABOROLE COMPOUNDS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/154759 International Application No.: PCT/US2013/032014
Publication Date: 17.10.2013 International Filing Date: 15.03.2013
IPC:
A61K 31/69 (2006.01) ,A61K 31/195 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
69
Boron compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
195
having an amino group
Applicants: ALLEY, Michael Richard Kevin[GB/US]; US
WIDDOWSON, Katherine[US/US]; US
ANACOR PHARMACEUTICALS, INC.[US/US]; 1020 E. Meadow Circle Palo Alto, California 94303, US
GLAXOSMITHKLINE LLC[US/US]; One Franklin Plaza 200 North16th Street Philadelphia, Pennsylvania 19406, US
Inventors: ALLEY, Michael Richard Kevin; US
WIDDOWSON, Katherine; US
Agent: CARTER, Barbara, J.; c/o GlaxoSmithKline Global Patents Five Moore Drive PO Box 13398 Research Triangle Park, North Carolina 27709, US
Priority Data:
61/624,29414.04.2012US
Title (EN) BENZOXABOROLE COMPOUNDS AND USES THEREOF
(FR) COMPOSÉS DE TYPE BENZOXABOROLE ET LEURS UTILISATIONS
Abstract:
(EN) Norvaline and/or other amino acids that are capable of being acylated onto tRNALeu by LeuRS, in combination with substituted benzoxaboroles, such as a compound having a structure according to formula III: and methods for decreasing the frequency of resistance and/or reducing the rate of resistance and/or suppressing the emergence of resistance that develops in bacteria exposed to a substituted benzoxaborole or salt thereof by administering a combination of a substituted benzoxaborole such as a compound of formula III or salt thereof and an amino acid or a salt thereof.
(FR) La présente invention concerne la norvaline et/ou d'autres acides aminés qui peuvent être acylés sur des ARNtLeu par des LeuRS, et qui sont combinés à des benzoxaboroles substitués, par exemple à un composé dont la structure correspond à la formule III, ainsi que des méthodes permettant d'entraîner une baisse de la fréquence de la résistance et/ou une réduction du taux de résistance et/ou une inhibition de l'apparition de la résistance qui se développe chez des bactéries exposées à un benzoxaborole substitué ou à un sel de celui-ci, grâce à l'administration d'une combinaison associant un benzoxaborole substitué, tel qu'un composé de formule III ou un sel de celui-ci, et un acide aminé ou un sel de celui-ci.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)