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1. WO2013154570 - SYNTHETIC MECHANICAL HEMOSTATIC COMPOSITION, METHOD OF MAKING AND USE THEREOF

Publication Number WO/2013/154570
Publication Date 17.10.2013
International Application No. PCT/US2012/033398
International Filing Date 12.04.2012
IPC
C08L 101/16 2006.01
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
101Compositions of unspecified macromolecular compounds
16the macromolecular compounds being biodegradable
C08L 69/00 2006.01
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
69Compositions of polycarbonates; Compositions of derivatives of polycarbonates
C08L 67/04 2006.01
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
67Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
04Polyesters derived from hydroxy carboxylic acids, e.g. lactones
A61K 31/365 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
365Lactones
A61P 7/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
04Antihaemorrhagics; Procoagulants; Haemostatatic agents; Antifibrinolytic agents
CPC
A61K 31/74
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
74Synthetic polymeric materials
A61P 7/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
04Antihaemorrhagics; Procoagulants; Haemostatatic agents; Antifibrinolytic agents
C08G 63/64
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
63Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
64Polyesters containing both carboxylic ester groups and carbonate groups
C08G 63/664
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
63Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
66Polyesters containing oxygen in the form of ether groups
664derived from hydroxy carboxylic acids
C08L 67/04
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
67Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain
04Polyesters derived from hydroxycarboxylic acids, e.g. lactones
Applicants
  • POLY-MED, INC. [US]/[US] (AllExceptUS)
  • GRAY, Kenneth, David, Jr. [US]/[US] (UsOnly)
  • TAYLOR, Michael, Scott [US]/[US] (UsOnly)
Inventors
  • GRAY, Kenneth, David, Jr.
  • TAYLOR, Michael, Scott
Agents
  • WANG, Ping
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SYNTHETIC MECHANICAL HEMOSTATIC COMPOSITION, METHOD OF MAKING AND USE THEREOF
(FR) COMPOSITION HÉMOSTATIQUE MÉCANIQUE SYNTHÉTIQUE, PROCÉDÉ DE FABRICATION ET D'UTILISATION DE CETTE DERNIÈRE
Abstract
(EN)
A biocompatible, polymeric composition is disclosed. The composition comprises a base polymer comprising (i) a prepolymer comprising para-dioxanone (PDO) and trimethylene carbonate (TMC); and (ii) an end-graft polymer chain comprising a polylactone. Also disclosed are a method for treating bleeding from bone or bony structures using the composition, a method for filling a void or correct a defect in a bone using the composition, and a method for producing the biocompatible, polymeric composition of the present application.
(FR)
La présente invention concerne une composition polymère biocompatible. La composition contient un polymère de base comprenant (i) un prépolymère comprenant de la para-dioxanone (PDO) et du carbonate de triméthylène (TMC) ; et (ii) une chaîne polymère à greffage terminal comprenant une polylactone. L'invention concerne également un procédé de traitement des saignements provenant d'un os ou de structures osseuses au moyen de la composition, un procédé de remplissage d'un vide ou de correction d'un défaut dans un os au moyen de la composition et un procédé de production de la composition polymère biocompatible.
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