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1. (WO2013154336) HOLLOW MICRONEEDLE AND SUBRETINAL SYRINGE FOR SUBRETINAL INJECTION OR EXTRACTION
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/154336 International Application No.: PCT/KR2013/002971
Publication Date: 17.10.2013 International Filing Date: 09.04.2013
IPC:
A61M 5/178 (2006.01) ,A61M 5/158 (2006.01) ,A61F 9/007 (2006.01)
Applicants: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY[KR/KR]; 1FL., Yonsei Univ., Engineering Research Park 50 Yonsei-ro Seodaemun-gu Seoul 120-752, KR
Inventors: JUNG, Hyung Il; KR
LEE, Chang Yeol; KR
LEE, Kwang; KR
LEE, Sung Ho; KR
YOU, Yong Sung; KR
Agent: YANG, Boo-Hyun; Suite 301, Chungdong Building 1659-2 Inhundong Gwanak-gu Seoul 151-832, KR
Priority Data:
10-2012-003655409.04.2012KR
Title (EN) HOLLOW MICRONEEDLE AND SUBRETINAL SYRINGE FOR SUBRETINAL INJECTION OR EXTRACTION
(FR) MICROAIGUILLE CREUSE ET SERINGUE SOUS-RÉTINIENNE POUR INJECTION OU EXTRACTION SOUS-RÉTINIENNE
(KO) 망막하 주사 또는 추출용 중공형 마이크로니들 및 망막하 주사기
Abstract: front page image
(EN) The present invention relates to a method for manufacturing a hollow microneedle for subretinal injection or extraction, wherein the method comprises the steps of: (a) applying a viscous material solution onto the surface of a substrate; (b) placing a frame in contact with the viscous material solution; (c) manufacturing a solid microneedle by lifting the substrate, the frame, or the substrate and the frame so as to space apart the contacted frame and the substrate; (d) imparting a curved shape to the solid microneedle during step (c) or after completing step (c); (e) depositing a metal onto the solid microneedle to which the curved shape has been imparting; (f) plating the solid microneedle, onto which the metal has been deposited, with a metal; (g) bevel-cutting the tip of the solid microneedle that has been plated with the metal; and (h) removing the solid microneedle, to thereby achieve a curved hollow microneedle. The microneedle for subretinal injection or extraction is made of metal, thereby providing the strength and force for penetrating the sclera and retina. Due to the length and the angle of curvature, the microneedle for subretinal injection or extraction of the present invention can reach a suitable subretinal site, such as the midperiphery at which optic nerves are accumulated, and thus the present invention is effective for delivering a drug and can enhance the effectiveness of the drug.
(FR) La présente invention concerne un procédé de fabrication d'une microaiguille creuse pour injection ou extraction sous-rétinienne, le procédé comprenant les étapes suivantes : (a) application d'une solution de matériau visqueux sur la surface d'un substrat ; (b) placement d'un cadre en contact avec la solution de matériau visqueux ; (c) fabrication d'une microaiguille pleine en soulevant le substrat, le cadre, ou le substrat et le cadre de façon à séparer le cadre et le substrat qui étaient en contact ; (d) attribution d'une forme incurvée à la microaiguille pleine pendant l'étape (c) ou après achèvement de l'étape (c) ; (e) dépôt d'un métal sur la microaiguille pleine à laquelle a été donnée une forme incurvée ; (f) placage de la microaiguille pleine, sur laquelle un métal a été déposé, avec un métal ; (g) coupe en biseau de la pointe de la microaiguille pleine qui a été plaquée avec le métal ; et (h) retrait de la microaiguille pleine, de façon à obtenir une microaiguille creuse incurvée. La microaiguille pour injection ou extraction sous-rétinienne est faite de métal, ce qui lui donne la robustesse et la force pour pénétrer dans la sclère et la rétine. Grâce à sa longueur et à son angle de courbure, la microaiguille pour injection ou extraction sous-rétinienne de la présente invention peut atteindre un site sous-rétinien approprié, comme la périphérie moyenne au niveau de laquelle les nerfs optiques s'accumulent, et la présente invention est donc efficace pour administrer un médicament et peut améliorer l'efficacité du médicament.
(KO) 본 발명은 (a) 기판 표면에 점성물질의 용액을 도포하는 단계; (b) 상기 점성물질의 용액과 프레임을 접촉시키는 단계; (c) 상기 접촉된 프레임과 기판이 이격되도록 기판, 프레임 또는 기판과 프레임을 리프팅 하여 솔리드 마이크로니들를 제조하는 단계; (d) 상기 단계 (c) 과정 중 또는 상기 단계 (c) 과정이 종료된 후 상기 솔리드 마이크로니들에 만곡형(curved shape)을 부여하는 단계; (e) 상기 만곡형(curved shape)이 부여된 솔리드 마이크로니들에 금속 증착하는 단계; (f) 상기 금속 증착된 솔리드 마이크로니들를 금속 도금하는 단계; (g) 상기 금속 도금된 솔리드 마이크로니들의 선단부를 베벨 절삭하는 단계; 및 (h) 상기 솔리드 마이크로니들를 제거하여 만곡형이 부여된 중공형 마이크로니들를 수득하는 단계를 포함하는 망막하 주사 또는 추출용 중공형 마이크로니들의 제조방법을 제공한다. 본 발명의 망막하 주사 또는 추출용 중공형 마이크로니들은 금속으로 이루어져 있어 공막 및 망막을 통과할 수 있는 강도 또는 힘이 있다. 본 발명의 망막하 주사 또는 추출용 중공형 마이크로니들은 길이 및 만곡앵글이 망막하의 적합한 위치, 예를 들어 시신경이 밀집한 망막하 중심부까지 도달 할 수 있어 약물을 전달하는 데 효과적이며 약물의 효과를 증진할 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)