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1. (WO2013153361) GENE EXPRESSSION FROM MITOTICALLY STABLE EPISOMES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/153361 International Application No.: PCT/GB2013/050795
Publication Date: 17.10.2013 International Filing Date: 27.03.2013
IPC:
C12N 15/67 (2006.01) ,C12N 15/867 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
67
General methods for enhancing the expression
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
86
Viral vectors
867
Retroviral vectors
Applicants: ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE[GB/GB]; Royal Holloway University of London Egham Surrey TW20 0EX, GB
Inventors: DICKSON, George; GB
YANEZ-MUNOS, Rafael; GB
KYMALAINEN, Hanna; GB
Agent: HUTTER, Anton; Venner Shipley LLP 200 Aldersgate London EC1A 4HD, GB
Priority Data:
1206455.612.04.2012GB
Title (EN) GENE EXPRESSSION FROM MITOTICALLY STABLE EPISOMES
(FR) EXPRESSION GÉNIQUE À PARTIR D'ÉPISOMES MITOTIQUEMENT STABLES
Abstract:
(EN) The invention provides a method of expressing a transgene in a host cell. The method comprises exposing a host cell, which comprises a genetic construct comprising a transgene, to conditions which substantially block mitosis in the host cell, such that the construct forms a mitotically stable episome resulting in expression of the transgene. The invention extends to the use of such constructs for expressing transgenes in a range of different medical and heterologous protein production applications.
(FR) Cette invention concerne un procédé d'expression d'un transgène dans une cellule hôte, le procédé comprenant l'exposition de la cellule hôte, qui contient un produit de recombinaison génétique comprenant un transgène, à des conditions qui bloquent sensiblement la mitose dans la cellule hôte, de façon que le produit de recombinaison forme un épisome mitotiquement stable permettant l'expression du transgène. Cette invention s'étend à l'utilisation de ces produits de recombinaison pour exprimer des transgènes dans tout un éventail d'applications de production de protéines à visée médicale et hétérologues différentes.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)