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1. (WO2013152741) 4-SUBSTITUENT-2-HYDROXYLMORPHOLINE-3-ONE AND PREPARATION METHOD THEREOF

Pub. No.:    WO/2013/152741    International Application No.:    PCT/CN2013/074202
Publication Date: Fri Oct 18 01:59:59 CEST 2013 International Filing Date: Tue Apr 16 01:59:59 CEST 2013
IPC: C07D 265/32
C07D 413/06
Applicants: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
浙江海正药业股份有限公司
SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY
上海医药工业研究院
Inventors: ZHANG, Fuli
张福利
LIU, Chonghao
刘崇皓
QIU, Pengcheng
裘鹏程
CHAI, Jian
柴健
CAI, Qingfeng
蔡青峰
Title: 4-SUBSTITUENT-2-HYDROXYLMORPHOLINE-3-ONE AND PREPARATION METHOD THEREOF
Abstract:
A molecule with neuro activities, especially 4-substituent-2-hydroxylmorpholine-3-one, as a new intermediate of neurokinin-1 receptor antagonist Aprepitant, and preparation method thereof.