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1. WO2013152476 - PROCESS FOR THE PREPARATION OF BENZYLBENZENE SGLT2 INHIBITORS

Publication Number WO/2013/152476
Publication Date 17.10.2013
International Application No. PCT/CN2012/073697
International Filing Date 10.04.2012
IPC
C07D 309/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
309Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
02having no double bonds between ring members or between ring members and non-ring members
08with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
10Oxygen atoms
C07C 39/367 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
39Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
24Halogenated derivatives
367polycyclic non-condensed, containing only six-membered aromatic rings, e.g. halogenated poly-(hydroxy-phenyl)alkanes
A61K 31/70 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
CPC
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
C07C 2601/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
02with a three-membered ring
C07C 29/147
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
29Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
132by reduction of an oxygen containing functional group
136of >C=O containing groups, e.g. —COOH
147of carboxylic acids or derivatives thereof
C07C 37/055
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
37Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
01by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
055the substituted group being bound to oxygen, e.g. ether group
C07C 37/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
37Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
11by reactions increasing the number of carbon atoms
16by condensation involving hydroxy groups of phenols or alcohols or the ether or mineral ester group derived therefrom
C07C 39/15
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
39Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
12polycyclic with no unsaturation outside the aromatic rings
15with all hydroxy groups on non-condensed rings ; , e.g. phenylphenol
Applicants
  • THERACOS, INC. [US]/[US] (AllExceptUS)
  • XU, Baihua [CN]/[US] (UsOnly)
  • LV, Binhua [CN]/[CN] (UsOnly)
  • XU, Ge [CN]/[CN] (UsOnly)
  • SEED, Brian [US]/[US] (UsOnly)
  • ROBERGE, Jacques [CA]/[US] (UsOnly)
Inventors
  • XU, Baihua
  • LV, Binhua
  • XU, Ge
  • SEED, Brian
  • ROBERGE, Jacques
Agents
  • SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR THE PREPARATION OF BENZYLBENZENE SGLT2 INHIBITORS
(FR) PROCÉDÉ DE PRÉPARATION D'INHIBITEURS DE SGLT2 BENZYLBENZÈNE
Abstract
(EN)
Provided are methods of making compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides synthetic intermediates useful for preparing such compounds.
(FR)
L'invention concerne des procédés de préparation de composés présentant un effet inhibiteur sur le co-transporteur de glucose dépendant du sodium SGLT. L'invention concerne également des intermédiaires synthétiques utiles pour la préparation de tels composés.
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